Paper Info
Title
Methhc: A Database Of Dna Methylation And Gene Expression In Human Cancer
Abstract
We present MethHC (http://MethHC.mbc.nctu.edu.tw), a database comprising a systematic integration of a large collection of DNA methylation data and mRNA/microRNA expression profiles in human cancer. DNA methylation is an important epigenetic regulator of gene transcription, and genes with high levels of DNA methylation in their promoter regions are transcriptionally silent. Increasing numbers of DNA methylation and mRNA/microRNA expression profiles are being published in different public repositories. These data can help researchers to identify epigenetic patterns that are important for carcinogenesis. MethHC integrates data such as DNA methylation, mRNA expression, DNA methylation of microRNA gene and microRNA expression to identify correlations between DNA methylation and mRNA/microRNA expression from TCGA (The Cancer Genome Atlas), which includes 18 human cancers in more than 6000 samples, 6548 microarrays and 12 567 RNA sequencing data.
Year
DOI
Venue
2015
10.1093/nar/gku1151
NUCLEIC ACIDS RESEARCH
Field
DocType
Volume
RNA-Directed DNA Methylation,Cancer epigenetics,Biology,Epigenomics,Illumina Methylation Assay,MicroRNA Gene,DNA methylation,Human genome,Genetics,Molecular biology,Database,Epigenetics
Journal
43
Issue
ISSN
Citations 
D1
0305-1048
6
PageRank 
References 
Authors
0.46
6
7
Name
Order
Citations
PageRank
Weiyun Huang112710.15
Sheng-Da Hsu231524.16
Hsi-Yuan Huang31538.27
Yi-Ming Sun460.46
Chih-Hung Chou517611.55
Shun-Long Weng61326.40
Hsien-Da Huang783563.83