Paper Info
Title
The GLOBE 3D Genome Platform - Towards A Novel System-Biological Paper Tool to Integrate the Huge Complexity of Genome Organization and Function.
Abstract
Genomes are tremendous co-evolutionary holistic systems for molecular storage, processing and fabrication of information Their system-biological complexity remains, however, still largely mysterious, despite immense sequencing achievements and huge advances in the understanding of the general sequential, three-dimensional and regulatory organization. Here, we present the GLOBE 3D Genome Platform a completely novel grid based virtual "paper" tool and in fact the first system-biological genome browser integrating the holistic complexity of genomes in a single easy comprehensible platform Based on a detailed study of biophysical and IT requirements, every architectural level from sequence to morphology of one or several genomes can be approached in a real and in a symbolic representation simultaneously and navigated by continuous scale-free zooming within a unique three-dimensional OpenGL and grid driven environment In principle an unlimited number of multi-dimensional data sets can be visualized, customized in terms of arrangement, shape, colour, and texture etc as well as accessed and annotated Individually or in groups using internal or external data bases/facilities Any information can be searched and correlated by importing or calculating simple relations in real-time using grid resources A general correlation and application platform for more complex correlative analysis and a front-end for system-biological simulations both using again the huge capabilities of grid infrastructures is currently under development Hence, the GLOBE 3D Genome Platform is an example of a grid based approach towards a virtual desktop for genomic work combining the three fundamental distributed resources I) visual data representation, II) data access and management, and III) data analysis and creation Thus, the GLOBE 3D Genome Platform is the novel system-biology oriented information system urgently needed to access, present, annotate, and to simulate the holistic genome complexity in a unique gateway towards a real understanding, educative presentation and curative manipulation planning of this tremendous evolutionary information grail - genomes
Year
DOI
Venue
2009
10.3233/978-1-60750-027-8-105
Studies in Health Technology and Informatics
Keywords
Field
DocType
Genome organization,integrative system-biology,extreme visualization,three-dimensional virtual environment,grid and GPU computing
Genome,Data science,Information system,Data mining,External Data Representation,Genome browser,Zoom,Virtual desktop,Data access,Medicine,Grid
Conference
Volume
ISSN
Citations 
147
0926-9630
3
PageRank 
References 
Authors
0.55
3
5
Name
Order
Citations
PageRank
Tobias A Knoch1618.01
Michael Lesnussa261.55
Nick Kepper382.95
Hubert B. Eussen430.55
Frank G Grosveld5323.12