Paper Info
Title
Risk stratification of ICU patients using topic models inferred from unstructured progress notes.
Abstract
We propose a novel approach for ICU patient risk stratification by combining the learned "topic" structure of clinical concepts (represented by UMLS codes) extracted from the unstructured nursing notes with physiologic data (from SAPS-I) for hospital mortality prediction. We used Hierarchical Dirichlet Processes (HDP), a non-parametric topic modeling technique, to automatically discover "topics" as shared groups of co-occurring UMLS clinical concepts. We evaluated the potential utility of the inferred topic structure in predicting hospital mortality using the nursing notes of 14,739 adult ICU patients (mortality 14.6%) from the MIMIC II database. Our results indicate that learned topic structure from the first 24-hour ICU nursing notes significantly improved the performance of the SAPS-I algorithm for hospital mortality prediction. The AUC for predicting hospital mortality from the first 24 hours of physiologic data and nursing text notes was 0.82. Using the physiologic data alone with the SAPS-I algorithm, an AUC of 0.72 was achieved. Thus, the clinical topics that were extracted and used to augment the SAPS-I algorithm significantly improved the performance of the baseline algorithm.
Year
Venue
Keywords
2012
AMIA
area under curve,unified medical language system,algorithms,risk assessment,natural language processing,severity of illness index
Field
DocType
Volume
Nursing notes,Topic structure,Severity of illness,Nursing records,Risk assessment,Intensive care medicine,Topic model,Unified Medical Language System,Medicine
Conference
2012
ISSN
Citations 
PageRank 
1942-597X
17
1.57
References 
Authors
6
5
Name
Order
Citations
PageRank
Li-wei H Lehman119218.54
Mohammed Saeed27410.04
William J. Long321827.94
Joon Lee4295.54
Roger G. Mark524330.74