Title
Deep Learning of Image Features from Unlabeled Data for Multiple Sclerosis Lesion Segmentation.
Abstract
A new automatic method for multiple sclerosis (MS) lesion segmentation in multi-channel 3D MR images is presented. The main novelty of the method is that it learns the spatial image features needed for training a supervised classifier entirely from unlabeled data. This is in contrast to other current supervised methods, which typically require the user to preselect or design the features to be used. Our method can learn an extensive set of image features with minimal user effort and bias. In addition, by separating the feature learning from the classifier training that uses labeled (pre-segmented data), the feature learning can take advantage of the typically much more available unlabeled data. Our method uses deep learning for feature learning and a random forest for supervised classification, but potentially any supervised classifier can be used. Quantitative validation is carried out using 1450 T2-weighted and PD-weighted pairs of MRIs of MS patients, with 1400 pairs used for feature learning (100 of those for labeled training), and 50 for testing. The results demonstrate that the learned features are highly competitive with hand-crafted features in terms of segmentation accuracy, and that segmentation performance increases with the amount of unlabeled data used, even when the number of labeled images is fixed.
Year
DOI
Venue
2014
10.1007/978-3-319-10581-9_15
Lecture Notes in Computer Science
Keywords
Field
DocType
Multiple sclerosis lesions,MRI,machine learning,segmentation,deep learning,random forests
Semi-supervised learning,Pattern recognition,Segmentation,Feature (computer vision),Computer science,Supervised learning,Unsupervised learning,Artificial intelligence,Deep learning,Random forest,Machine learning,Feature learning
Conference
Volume
ISSN
Citations 
8679
0302-9743
7
PageRank 
References 
Authors
0.71
9
5
Name
Order
Citations
PageRank
Youngjin Yoo11229.07
Brosch Tom21708.29
Anthony Traboulsee31175.82
David K. B. Li41318.27
Roger C. Tam524416.61