Paper Info
Title
Stroke unit of integrative medicine for post stroke comorbid anxiety and depression: A systematic review and meta-analysis of 25 randomized controlled trials
Abstract
Objective: To review the effectiveness and safety of stroke unit of integrative medicine for post stroke comorbid anxiety and depression (PSCAD) systematically. Methods: Electronic databases of MEDLINE, Chinese Biomedical Literature Database, VIP Database, Wan-fang Database, CNKI Database were handled by computer retrieval, and Journal of Traditional Chinese Medicine were manually searched for papers of randomized controlled trial (RCT) on Chinese herbal medicine (CHM) plus pharmacotherapy versus pharmacotherapy in treating PSCAD. In accordance with the inclusion criteria, two reviewers independently screened the related literatures, assessed the risk of bias and extracted the literature data, while the software of RevMan5.2.6 was used for the combining data analysis. Results: A total of 25 studies involving 2,044 patients were identified for this review. Meta-analysis results indicated that the integrative group i.e. CHM plus pharmacotherapy group showed more effective for PSCAD (OR=3.63, 95%CI (2.67, 4.95)), lower HAMD (Hamilton depression scale) score (WMD=-3.84, 95%CI (-4.66, -3.02)), and less adverse events (OR=0.71, 95%CI (0.51, 0.97)) compared with the control group i.e. routine pharmacotherapy group. Conclusion: The meta-analysis indicated that the integrative medicine treatment could be more helpful in strengthening the clinical efficacy and reducing the incidence of adverse events in the treatment of PSCAD compared with routine pharmacotherapy. However, due to the small sample size of included trials and the relatively low-rating quality in the majority of studies, further large-scale, multi-center and rigorously-designed trials should be required to confirm the effectiveness and safety of integrative medicine for PSCAD.
Year
DOI
Venue
2014
10.1109/BIBM.2014.6999360
BIBM
Keywords
Field
DocType
post stroke comorbid anxiety-and-depression,literature data extraction,revman5.2.6,low-rating quality,post stroke depression(psd),medical disorders,computer retrieval,medline,pharmacotherapy,electronic health records,integrative group,multicenter trials,integrative medicine,stroke unit effectiveness,large-scale trials,vip database,data analysis,rigorously-designed trials,systematic review,randomized controlled trial,hamilton depression scale,inclusion criteria,feature extraction,cnki database,stroke unit safety,risk assessment,risk management,software,chinese herbal medicine (chm),journal-of-traditional chinese medicine,meta-analysis,chinese biomedical literature database,randomized controlled trials,wan-fang database,randomized controlled trial (rct),electronic databases,integrative medicine treatment,comorbid anxiety and depression,chinese herbal medicine,patient treatment,clinical efficacy strengthening,databases,data mining
Integrative medicine,Computer science,Physical therapy,Stroke,Pharmacotherapy,Randomized controlled trial,Traditional Chinese medicine,Hamd,Bioinformatics,Meta-analysis,MEDLINE
Conference
ISSN
Citations 
PageRank 
2156-1125
0
0.34
References 
Authors
0
5
Name
Order
Citations
PageRank
Lingfeng Zeng125.45
Changrong Meng223.08
Zhaohui Liang32615.31
Xiangji Huang41551159.34
Ziping Li527.48