Name
Title | ||
|---|---|---|
Higher dimensional fMRI connectivity dynamics show reduced dynamism in schizophrenia patients |
Abstract | ||
|---|---|---|
Assessments of functional connectivity between brain networks is a fixture of resting state fMRI research. Until very recently most of this work proceeded from an assumption of stationarity in resting state network connectivity. In the last few years however, interest in moving beyond this simplifying assumption has grown considerably. Applying group temporal independent component analysis (tICA) to a set of time-varying functional network connectivity (FNC) matrices derived from a large multi-site fMRI dataset (N=314; 163 healthy, 151 schizophrenia patients), we obtain a set of five basic correlation patterns (component spatial maps (SMs)) from which observed FNCs can be expressed as mutually independent linear combinations, ie. the coefficient on each SM in the linear combination is statistically independent of the others. We study dynamic properties of network connectivity as they are reflected in this five-dimensional space, and report stark differences in connectivity dynamics between schizophrenia patients and healthy controls. |
Year | DOI | Venue |
|---|---|---|
2014 | 10.1109/PRNI.2014.6858534 | Tubingen |
Keywords | Field | DocType |
biomedical MRI,independent component analysis,medical disorders,basic correlation patterns,brain networks,component spatial maps,connectivity dynamics,five-dimensional space,functional connectivity assessments,group temporal independent component analysis,higher dimensional fMRI connectivity dynamics,multisite fMRI dataset,mutually independent linear combinations,reduced dynamism,resting state fMRI research fixture,resting state network connectivity,schizophrenia patients,stark differences,stationarity assumption,time-varying functional network connectivity,dynamics,fMRI,independent component analysis,network connectivity,schizophrenia | Dynamism,Network connectivity,Psychology,Cognitive psychology,Independent component analysis,Artificial intelligence,Schizophrenia | Conference |
ISSN | Citations | PageRank |
2330-9989 | 1 | 0.55 |
References | Authors | |
1 | 4 | |
Name | Order | Citations | PageRank |
|---|---|---|---|
| Robyn L. Miller | 1 | 1 | 0.55 |
| Maziar Yaesoubi | 2 | 1 | 0.55 |
| Vince D. Calhoun | 3 | 1 | 0.55 |
| Shruti Gopal | 4 | 1 | 0.55 |