Name
Abstract | ||
|---|---|---|
We developed a discrete time, structured, mathematical model describing the epidemiology of X-linked recessive diseases, a class of genetic disorders. The model accounts for both de novo mutations and distinct reproduction rates of procreating couples depending on their health conditions. We found the exact solution to the model when de novo mutations are not significant and negligible reproduction rates are assigned to affected males. Our results have relevance for both system modeling and genetic epidemiology. |
Year | DOI | Venue |
|---|---|---|
2014 | 10.1109/MED.2014.6961588 | Control and Automation |
Keywords | Field | DocType |
diseases,epidemics,x-linked recessive diseases,de novo mutations,discrete time mathematical model,distinct reproduction rates,genetic disorders,genetic epidemiology,nonlinear discrete time epidemiological model,structured mathematical model,system modeling,mathematical model,dna,sociology,statistics | X-linked recessive inheritance,De novo mutations,Nonlinear system,Demography,Control theory,Computer science,Genetic epidemiology,Epidemiology,Discrete time and continuous time,Genetics,Dominance (genetics) | Conference |
ISSN | Citations | PageRank |
2325-369X | 2 | 0.58 |
References | Authors | |
2 | 3 | |
Name | Order | Citations | PageRank |
|---|---|---|---|
| Del Vecchio, C. | 1 | 2 | 1.25 |
| Luigi Glielmo | 2 | 64 | 6.72 |
| Martin Corless | 3 | 34 | 9.52 |