Name
Title | ||
|---|---|---|
A potential translational approach for bone tissue engineering through endochondral ossification. |
Abstract | ||
|---|---|---|
Bone defect repair is a significant clinical challenge in orthopedic surgery. Despite tremendous efforts, the majority of the current bone tissue engineering strategies depend on bone formation via intramembranous ossification (IO), which often results in poor vascularization and limited-area bone regeneration. Recently, there has been increasing interest in exploring bone regeneration through a cartilage-mediated process similar to endochondral ossification (EO). This method is advantageous because long bones are originally developed through EO and moreover, vascularization is an inherent step of this process. Therefore, it may be possible to effectively employ the EO method for the repair and regeneration of large and segmental bone defects. Although a number of studies have demonstrated engineered bone formation through EO, there are no approaches aiming for their clinical translation. In this study, we propose a strategy modeled after the U.S. Food and Drug Administration (FDA) approved autologus chondrocyte implantation (ACI) procedure. In its implementation, we concentrated human bone marrow aspirate via a minimally manipulated process and demonstrated the potential of human bone marrow derived cells for in vitro pre-cartilage template formation and bone regeneration in vivo. |
Year | DOI | Venue |
|---|---|---|
2014 | 10.1109/EMBC.2014.6944482 | EMBC |
Keywords | Field | DocType |
limited-area bone regeneration,cartilage-mediated process,cellular biophysics,orthopaedics,minimally manipulated process,eo method,biomedical materials,long bones,tissue engineering,bone formation,prosthetics,human bone marrow derived cells,bone,endochondral ossification,human bone marrow aspirate,fda,bone tissue engineering strategies,large bone defects,clinical translation,u.s. food and drug administration,bone defect repair,aci,autologus chondrocyte implantation procedure,bone regeneration in vivo,io,segmental bone defects,orthopedic surgery,in vitro precartilage template formation,biomembranes,vascularization,surgery,intramembranous ossification | Biomedical engineering,Endochondral ossification,Computer science,Bone cell,Chondrocyte,Bone healing,Bone tissue,Bone marrow,Intramembranous ossification,Bone remodeling | Conference |
Volume | ISSN | Citations |
2014 | 1557-170X | 0 |
PageRank | References | Authors |
0.34 | 0 | 9 |
Name | Order | Citations | PageRank |
|---|---|---|---|
| Paiyz E Mikael | 1 | 0 | 0.34 |
| Xiaonan Xin | 2 | 0 | 0.34 |
| Maria Urso | 3 | 0 | 0.34 |
| Xi Jiang | 4 | 1 | 1.69 |
| Liping Wang | 5 | 0 | 0.34 |
| Brian Barnes | 6 | 0 | 0.34 |
| Alexander C Lichtler | 7 | 0 | 0.34 |
| David W. Rowe | 8 | 8 | 3.19 |
| Syam P Nukavarapu | 9 | 0 | 0.68 |