Name
Abstract | ||
|---|---|---|
Noninvasive functional imaging of awake, unrestrained small animals using motion-compensation removes the need for anesthetics and enables an animal's behavioral response to stimuli or administered drugs to be studied concurrently with imaging. While the feasibility of motion-compensated radiotracer imaging of awake rodents using marker-based optical motion tracking has been shown, markerless motion tracking would avoid the risk of marker detachment, streamline the experimental workflow, and potentially provide more accurate pose estimates over a greater range of motion. We have developed a stereoscopic tracking system which relies on native features on the head to estimate motion. Features are detected and matched across multiple camera views to accumulate a database of head landmarks and pose is estimated based on 3D-2D registration of the landmarks to features in each image. Pose estimates of a taxidermal rat head phantom undergoing realistic rat head motion via robot control had a root mean square error of 0.15 and 1.8 mm using markerless and marker-based motion tracking, respectively. Markerless motion tracking also led to an appreciable reduction in motion artifacts in motion-compensated positron emission tomography imaging of a live, unanesthetized rat. The results suggest that further improvements in live subjects are likely if nonrigid features are discriminated robustly and excluded from the pose estimation process. |
Year | DOI | Venue |
|---|---|---|
2014 | 10.1109/TMI.2014.2332821 | Medical Imaging, IEEE Transactions |
Keywords | Field | DocType |
feature extraction,image registration,medical image processing,motion compensation,motion estimation,optical tracking,phantoms,pose estimation,positron emission tomography,radioactive tracers,stereo image processing,3D-2D registration,administered drugs,anesthetics,animal behavioral response,awake animals,awake rodents,experimental workflow,feature detection,head landmarks,live subjects,marker detachment risk,marker-based motion tracking,marker-based optical motion tracking,markerless-based motion tracking,motion artifacts,motion-compensated positron emission tomography imaging,motion-compensated radiotracer imaging,motion-compensation,multiple camera,native features,noninvasive functional imaging,nonrigid features,pose estimation process,range of motion,realistic rat head motion,robot control,root mean square error,stereoscopic tracking system,stimuli,streamline,taxidermal rat head phantom,unanesthetized rat,unrestrained small animals,Markerless optical motion tracking,motion compensation,positron emission tomography (PET) | Computer vision,Motion capture,Stereoscopy,Imaging phantom,Tracking system,Feature extraction,Pose,Artificial intelligence,Positron emission tomography,Match moving,Physics | Journal |
Volume | Issue | ISSN |
33 | 11 | 0278-0062 |
Citations | PageRank | References |
4 | 0.49 | 12 |
Authors | ||
4 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Andre Kyme | 1 | 5 | 1.19 |
| Se, S. | 2 | 4 | 0.49 |
| Steven R. Meikle | 3 | 23 | 5.20 |
| Georgios I. Angelis | 4 | 6 | 2.25 |