Title
Sparse Principal Component Analysis for the parsimonious description of glucose variability in diabetes.
Abstract
Abnormal glucose variability (GV) is considered to be a risk factor for the development of diabetes complications. For its quantification from continuous glucose monitoring (CGM) data, tens of different indices have been proposed in the literature, but the information carried by them is highly redundant. In the present work, the Sparse Principal Component Analysis (SPCA) technique is used to select, from a wide pool of GV metrics, a smaller subset of indices that preserves the majority of the total original variance, providing a parsimonious but still comprehensive description of GV. In detail, SPCA is applied to a set of 25 literature GV indices evaluated on CGM time-series collected in 17 type 1 (T1D) and 13 type 2 (T2D) diabetic subjects. Results show that the 10 GV indices selected by SPCA preserve more than the 75% of the variance of the original set of 25 indices, both in T1D and T2D. Moreover, 6 indices of the parsimonious set are shared by T1D and T2D.
Year
DOI
Venue
2014
10.1109/EMBC.2014.6945151
EMBC
Keywords
Field
DocType
diabetes,diseases,type 2 diabetic subjects,patient monitoring,medical signal processing,glucose variability,total original variance,biochemistry,spca,cgm time-series,type 1 diabetic subjects,principal component analysis,time series,sparse principal component analysis,continuous glucose monitoring,blood
Econometrics,Computer vision,Computer science,Artificial intelligence,Machine learning,Principal component analysis
Conference
Volume
ISSN
Citations 
2014
1557-170X
1
PageRank 
References 
Authors
0.38
0
4
Name
Order
Citations
PageRank
C Fabris110.38
Andrea Facchinetti215228.83
Giovanni Sparacino327652.52
Claudio Cobelli4658113.31