Paper Info
Title
Impedance alterations in healthy and diseased mice during electrically-induced muscle contraction.
Abstract
Alterations in the health of muscles can be evaluated through the use of electrical impedance myography (EIM). To date, however, nearly all work in this field has relied upon the measurement of muscle at rest. To provide insight into the contractile mechanisms of healthy and disease muscle, we evaluated the alterations in the spectroscopic impedance behavior of muscle during the active process of muscle contraction. The gastrocnemii from a total of 13 mice were studied (5 wild type, 4 muscular dystrophy animals, and 4 amyotrophic lateral sclerosis animals). Muscle contraction was induced via monophasic current pulse stimulation of the sciatic nerve. Simultaneously, multisine EIM (1 kHz to 1 MHz) and force measurements of the muscle were performed. Stimulation was applied at 3 different rates to produce mild, moderate and strong contractions. We identified changes in both single and multifrequency data, as assessed by the Cole impedance model parameters. The processes of contraction and relaxation were clearly identified in the impedance spectra and quantified via derivative plots. Reductions in the center frequency fc were observed during the contraction consistent with increasing muscle fiber diameter. Different EIM stimulation rate-dependencies were also detected across the 3 groups of animals.
Year
DOI
Venue
2016
10.1109/TBME.2014.2320132
IEEE Trans. Biomed. Engineering
Keywords
DocType
Volume
Dynamic electrical impedance myography, multisine excitations, muscle, isometric contraction, time-varying impedance
Journal
PP
Issue
ISSN
Citations 
99
1558-2531
2
PageRank 
References 
Authors
0.53
2
5
Name
Order
Citations
PageRank
Benjamin Sanchez1177.49
Jia Li242.04
Tom Geisbush320.87
Ramon Bragos431.70
Seward B Rutkove553.44