Name
Title | ||
|---|---|---|
Efficacy of cathodal transcranial direct current stimulation in drug-resistant epilepsy: A proof of principle. |
Abstract | ||
|---|---|---|
It has been proved that Transcranial DCS (tDCS) can modulate cortical excitability, enhancing or decreasing, respectively by anodal or cathodal polarity. The short-term and lasting alterations induced by tDCS are strictly related to the charge density, duration of stimulation and the depth of neuron below the skull. Epilepsy represents a pathophysiological model of unbalanced relation between cortical excitation and inhibition. In this line, tDCS can be exploited to counterbalance the neuronal hyper-excitation through electric neural modulation. This paper aims at providing the efficacy of cathodal tDCS in reducing seizures' frequency in drug-resistant focal epilepsy. The study was single blind and sham-controlled with an observation period of one month during which the patients or the caregivers provided a detailed seizures' calendar (frequency as n°/week; basal, post sham and post tDCS). Patients received sham or real tDCS treatment on the 8th and 22th days. Two patients affected by focal resistant epilepsy were enrolled. They both underwent a consistent reduction of the seizures'frequency: about 70 % for Patient 1 and about 50% for Patient 2. This study represents the proof that cathodal tDCS may be efficient in reducing seizures'frequency in focal resistant epilepsy. |
Year | DOI | Venue |
|---|---|---|
2014 | 10.1109/EMBC.2014.6943645 | EMBC |
Keywords | Field | DocType |
neuronal hyperexcitation,seizure frequency reduction,cellular biophysics,medical disorders,bioelectric potentials,anodal polarity,neurophysiology,drug-resistant focal epilepsy,cathodal transcranial direct current stimulation,electric neural modulation,pathophysiological model,cathodal polarity,charge density,cortical excitation,physiological models,time 8 day,cortical inhibition,electric current,time 22 day,patient treatment,drugs | Neuroscience,Psychology,Drug Resistant Epilepsy,Proof of concept,Transcranial direct-current stimulation | Conference |
Volume | ISSN | Citations |
2014 | 1557-170X | 0 |
PageRank | References | Authors |
0.34 | 0 | 7 |
Name | Order | Citations | PageRank |
|---|---|---|---|
| Giovanni Assenza | 1 | 0 | 0.68 |
| Chiara Campana | 2 | 0 | 1.01 |
| Domenico Formica | 3 | 88 | 26.60 |
| Emiliano Schena | 4 | 106 | 43.86 |
| Fabrizio Taffoni | 5 | 58 | 13.31 |
| Giovanni Di Pino | 6 | 25 | 7.95 |
| Vincenzo Di Lazzaro | 7 | 0 | 1.01 |