Name
Abstract | ||
|---|---|---|
This paper reports diffusion weighted MRI measurements of cyclohexane in a novel diffusion tensor MRI phantom composed of hollow coaxial electrospun fibers (average diameter 10.2 μm). Recent studies of the phantom demonstrated its potential as a calibration standard at low b values (less than 1000 s/mm<;sup>2<;/sup>) for mean diffusivity and fractional anisotropy. In this paper, we extend the characterization of cyclohexane diffusion in this heterogeneous, anisotropic material to high b values (up to 5000 s/mm<;sup>2<;/sup>), where the apparent diffusive motion of the cyclohexane exhibits anomalous behavior (i.e., the molecular mean squared displacement increases with time raised to the fractional power 2α/β). Diffusion tensor MRI was performed at 9.4 T using an Agilent imaging scanner and the data fit to a fractional order Mittag-Leffler (generalized exponential) decay model. Diffusion along the fibers was found to be Gaussian (2α/β=l), while diffusion across the fibers was sub-diffusive (2α/β<;l). Fiber tract reconstruction of the data was consistent with scanning electron micrograph images of the material. These studies suggest that this phantom material may be used to calibrate MR systems in both the normal (Gaussian) and anomalous diffusion regimes. |
Year | DOI | Venue |
|---|---|---|
2014 | 10.1109/EMBC.2014.6943698 | EMBC |
Keywords | Field | DocType |
calibration standard,apparent diffusive motion,mr systems,anisotropic media,gaussian processes,agilent imaging scanner,fractional anisotropy,biodiffusion,normal diffusion regime,anisotropic material,diffusion weighted mri measurements,hollow coaxial electrospun fibers,diffusion tensor mri phantom,fiber tract reconstruction,size 10.2 mum,image reconstruction,electrospinning,biomedical mri,magnetic flux density 9.2 t,heterogeneous material,mean diffusivity,cyclohexane diffusion characterization,fractional order mittag-leffler decay model,anomalous behavior,gaussian diffusion,anomalous diffusion regime,scanning electron micrograph images,phantom material,phantoms,medical image processing | Diffusion MRI,Anisotropy,Fiber,Computer science,Fractional anisotropy,Imaging phantom,Thermal diffusivity,Nuclear magnetic resonance,Anomalous diffusion,Mean squared displacement | Conference |
Volume | ISSN | Citations |
2014 | 1557-170X | 1 |
PageRank | References | Authors |
0.43 | 3 | 6 |
Name | Order | Citations | PageRank |
|---|---|---|---|
| Allen Q Ye | 1 | 7 | 2.24 |
| Penny L Hubbard Cristinacce | 2 | 1 | 0.43 |
| Feng-Lei Zhou | 3 | 3 | 1.55 |
| Ziying Yin | 4 | 1 | 0.77 |
| Geoffrey J. M. Parker | 5 | 444 | 39.62 |
| Richard L. Magin | 6 | 139 | 15.12 |