Paper Info
Title
Electrical Impedance Tomography for assessing Ventilation/Perfusion mismatch for Pulmonary Embolism detection without interruptions in respiration
Abstract
Recent studies have shown high correlation between pulmonary perfusion mapping with impedance contrast enhanced Electrical Impedance Tomography (EIT) and standard perfusion imaging methods such as Computed Tomography (CT) and Single Photon Emission Computerized Tomography (SPECT). EIT has many advantages over standard imaging methods as it is highly portable and non-invasive. Contrast enhanced EIT uses hypertonic saline bolus instead of nephrotoxic contrast medium that are utilized by CT and nuclear Ventilation/Perfusion (V/Q) scans. However, current implementation of contrast enhanced EIT requires induction of an apnea period for perfusion measurement, rendering it disadvantageous compared with current gold standard imaging modalities. In the present paper, we propose the use of a wavelet denoising algorithm to separate perfusion signal from ventilation signal such that no interruption in patient's ventilation would be required. Furthermore, right lung to left lung perfusion ratio and ventilation ratio are proposed to assess the mismatch between ventilation and perfusion for detection of Pulmonary Embolism (PE). The proposed methodology was validated on an ovine model (n=3, 83.7±7.7 kg) with artificially induced PE in the right lung. The results showed a difference in right lung to left lung perfusion ratio between baseline and diseased states in all cases with all paired t-tests between baseline and PE yielding p <; 0.01, while the right lung to left lung ventilation ratio remained unchanged in two out of three experiments. Statistics were pooled from multiple repetitions of measurements per experiment.
Year
DOI
Venue
2014
10.1109/EMBC.2014.6945013
EMBC
Keywords
Field
DocType
diseases,electric impedance imaging,haemodynamics,image denoising,image reconstruction,lung,medical disorders,medical image processing,pneumodynamics,source separation,statistical analysis,wavelet transforms,SPECT,apnea period induction,artificially induced right lung PE,baseline lung states,computed tomography,diseased states,electrical impedance tomography,hypertonic saline bolus,impedance contrast enhanced EIT correlation,nephrotoxic contrast medium,noninvasive EIT,nuclear ventilation-perfusion scans,ovine model,paired t-tests,perfusion imaging methods,perfusion measurement,perfusion signal separation,portable EIT,pulmonary embolism detection,pulmonary perfusion mapping correlation,respiration interruptions,right lung-left lung perfusion ratio,right lung-left lung ventilation ratio,single photon emission computerized tomography,statistical analysis,ventilation signal separation,ventilation-perfusion mismatch assessment,wavelet denoising algorithm
Perfusion scanning,Ventilation perfusion mismatch,Pulmonary embolism,Respiration,Ventilation/perfusion ratio,Radiology,Medicine,Electrical impedance tomography
Conference
Volume
ISSN
Citations 
2014
1557-170X
0
PageRank 
References 
Authors
0.34
0
7
Name
Order
Citations
PageRank
Doan Trang Nguyen100.34
Aravinda Thiagalingam2193.60
Abhishek Bhaskaran300.34
Michael A Barry400.34
Jim Pouliopoulos500.34
C. T. Jin611822.68
Alistair L McEwan700.68