Name
Title | ||
|---|---|---|
Bayesian two-compartment and classic single-compartment minimal models: Comparison on insulin modified IVGTT and effect of experiment reduction |
Abstract | ||
|---|---|---|
Models describing plasma glucose and insulin concentration of an intravenous glucose tolerance test (IVGTT) allow a noninvasive cost-effective approach to estimate important indexes characterizing the efficiency of glucose-insulin control system, i.e., glucose effectiveness (S(G)) and insulin sensitivity (S(I)). To overcome some limitations of the classic single compartment minimal model (1CMM) of glucose kinetics , a two-compartment Bayesian minimal model (2CBMM) has been recently proposed for the standard IVGTT. This study aims to assess 2CBMM ability to describe the insulin-modified IVGTT (IM-IVGTT) which is the protocol of choice since it allows to study insulinopenic states. Both a full-length IM-IVGTT (240 min) as well as a reduced version (90 min) of it are studied. Results of the maximum a posteriori identification of IM-IVGTT (240 min) in 13 normals agree with those of standard IVGTT, i.e., a 42% decrease (P < 0.002) of S(G) and a 13% increase (P < 0.006) of S(I) with respect to ICMM. When identified from IM-IVGTT (90 min), 2CBMM not only provides S(G) and S(I) estimates 46% lower (P < 0.002) and 41% higher (P < 0.002) than 1CMM ones respectively, but also seems to overcome some limitations of the 240 min-based identification that probably arise because the minimal model is unable to properly account for the hyperglycemic hormonal response taking place in the second half of IM-IVGTT. |
Year | DOI | Venue |
|---|---|---|
2003 | 10.1109/TBME.2003.819850 | Biomedical Engineering, IEEE Transactions |
Keywords | Field | DocType |
Bayes methods,biochemistry,biocontrol,organic compounds,parameter estimation,physiological models,statistical analysis,sugar,240 min,90 min,Bayesian two-compartment minimal model,classic single-compartment minimal model,diabetes,efficiency,experiment reduction,full-length IM-IVGTT,glucose effectiveness,glucose-insulin control system,hyperglycemic hormonal response,important indexes,insulin concentration,insulin modified IVGTT,insulin sensitivity,insulinopenic states,intravenous glucose tolerance test,maximum a posteriori identification,noninvasive cost-effective approach,normals,plasma glucose concentration,protocol,reduced version | Minimal models,Intravenous Glucose Tolerance Test,Internal medicine,Computer science,Compartment (ship),Minimal model,Glucose tolerance test,Insulin,Insulin resistance,Endocrinology,Bayesian probability | Journal |
Volume | Issue | ISSN |
50 | 12 | 0018-9294 |
Citations | PageRank | References |
1 | 0.43 | 0 |
Authors | ||
3 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Callegari, T. | 1 | 1 | 0.43 |
| Andrea Caumo | 2 | 22 | 11.87 |
| Claudio Cobelli | 3 | 658 | 113.31 |