Title
Distributed computing for membrane-based modeling of action potential propagation
Abstract
Action potential propagation simulations with physiologic membrane currents and macroscopic tissue dimensions are computationally expensive. We, therefore, analyzed distributed computing schemes to reduce execution time in workstation clusters by parallelizing solutions with message passing. Four schemes were considered in two-dimensional monodomain simulations with the Beeler-Reuter membrane equations. Parallel speedups measured with each scheme were compared to theoretical speedups, recognizing the relationship between speedup and code portions that executed serially. A data decomposition scheme based on total ionic current provided the best performance. Analysis of communication latencies in that scheme led to a load-balancing algorithm in which measured speedups at 89 +/- 2% and 75 +/- 8% of theoretical speedups were achieved in homogeneous and heterogeneous clusters of workstations. Speedups in this scheme with the Luo-Rudy dynamic membrane equations exceeded 3.0 with eight distributed workstations. Cluster speedups were comparable to those measured during parallel execution on a shared memory machine.
Year
DOI
Venue
2000
10.1109/10.855932
Biomedical Engineering, IEEE Transactions
Keywords
Field
DocType
bioelectric potentials,biology computing,biomembranes,cardiology,digital simulation,distributed processing,physiological models,Luo-Rudy dynamic membrane equations,Peeler-Reuter membrane equations,action potential propagation,cardiac arrhythmia,cardiac electrophysiology,cluster speedups,data decomposition scheme,distributed computing,distributed workstations,heart,load-balancing algorithm,membrane-based modeling,numerical simulation,total ionic current,two-dimensional monodomain simulations
Cluster (physics),Shared memory,Computer simulation,Computer science,Workstation,Action potential,Execution time,Message passing,Speedup,Distributed computing
Journal
Volume
Issue
ISSN
47
8
0018-9294
Citations 
PageRank 
References 
5
1.10
3
Authors
4
Name
Order
Citations
PageRank
Porras, D.151.10
Jack M. Rogers2102.62
William M. Smith382.69
Andrew E. Pollard482.62