Name
Title | ||
|---|---|---|
Hybrid Integration of an Active Pixel Sensor and Microfluidics for Cytometry on a Chip |
Abstract | ||
|---|---|---|
Reported are motivations and approaches for the integration of custom sensors with microfluidic devices for cytometry on a chip and related fluid metering applications. To demonstrate, details of a digital 16-element mixed-signal CMOS active pixel optical sensor with adaptive spatial filtering is first described. The 0.18-mum CMOS fabricated sensor is then shown coupled to a microfluidic channel via a polymer encapsulated chip-on-board approach as well as a preferred flip-chip-on-glass hybrid integration approach. However, both approaches discussed possess attributes that are well suited for reliable high-volume production. Utilizing these two disparate assembly topologies, the intelligent sensor's general behavior, optical input dynamic range, and near-field sensitivity to polymer beads being transported in a microfluidic channel is explored. The findings suggest that discrete near-field sensor integration with microfluidics is a well-positioned integration approach for helping to obviate the need for precision analog-to-digital conversion, optical fiber microchannel coupling, and conventional microscopy for a set of relevant micro total analysis system applications. By opting instead for a hybrid multichip module approach to system integration, this study marks a slight departure in strategy relative to many common monolithic system-on-chip integration efforts |
Year | DOI | Venue |
|---|---|---|
2007 | 10.1109/TCSI.2006.887456 | Circuits and Systems I: Regular Papers, IEEE Transactions |
Keywords | Field | DocType |
CMOS image sensors,cellular biophysics,flip-chip devices,hybrid integrated circuits,lab-on-a-chip,microfluidics,spatial filters,system-on-chip,0.18 micron,CMOS fabricated sensor,active pixel sensor,cytometry on chip,discrete near-field sensor integration,flip-chip-on-glass,hybrid integration,intelligent sensor,microfluidics,polymer encapsulated chip-on-board,spatial filtering,Cytometer,flip-chip devices,intelligent sensors,microassembly,microelectromechanical devices,microfluidics,spatial filters | System on a chip,Intelligent sensor,Microfluidics,Total analysis system,Electronic engineering,Chip,CMOS sensor,Lab-on-a-chip,Mathematics,System integration | Journal |
Volume | Issue | ISSN |
54 | 1 | 1549-8328 |
Citations | PageRank | References |
8 | 1.92 | 1 |
Authors | ||
3 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Hartley, L. | 1 | 8 | 1.92 |
| K. V. I. S. Kaler | 2 | 34 | 7.35 |
| Orly Yadid-Pecht | 3 | 230 | 35.79 |