Name
Title | ||
|---|---|---|
Serotonin (5-HT) released by activated white blood cells in a biological fuel cell provide a potential energy source for electricity generation. |
Abstract | ||
|---|---|---|
Previous studies by our group have demonstrated the ability of white blood cells to generate small electrical currents, on the order of 1-3 microA/cm(2), when placed at the anode compartment of a proton exchange membrane (PEM) biological fuel cell. In this research study, an electrochemical technique is used to further investigate the electron transfer ability of activated white blood cells at interfacing electrodes in an attempt to elucidate the mechanism of electron transfer in the original biological fuel cell experiments. Cyclic voltammograms were obtained for human white blood cells using a three-electrode system. The working and counter electrodes were made from carbon felt and platinum, respectively, while the reference was a saturated calomel electrode (SCE). Oxidation peaks were observed at an average potential of 363 mV vs. SCE for the PMA/ionomycin activated white blood cells in glucose solution. However a corresponding reduction peak was not observed, suggesting irreversibility of the redox reaction. The cyclic voltammograms recorded for the white blood cells bear very close similarities to those of the neurotransmitter serotonin (5-HT). Serotonin released by white blood cells into the extracellular environment may be irreversibly oxidized at the working electrode in the cyclic voltammetry experiments and at the PEM biological fuel cell anode in our earlier electrochemical cell studies. |
Year | DOI | Venue |
|---|---|---|
2006 | 10.1109/IEMBS.2006.259280 | Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference |
Keywords | DocType | Volume |
reduction (chemical),cellular biophysics,serotonin,oxidation,neurophysiology,white blood cells,electrochemical electrodes,electrical currents,organic compounds,363 mv,three-electrode system,biochemistry,anode compartment,saturated calomel electrode,redox reaction,bioelectric phenomena,reduction,electricity generation,electron transfer ability,cyclic voltammograms,extracellular environment,proton exchange membrane biological fuel cell,voltammetry (chemical analysis),neurotransmitter,electrochemical technique,proton exchange membrane fuel cells,phorbol-12-myristate-13-acetate-ionomycin activation,energy source,biofuel,glucose solution,potential energy,electron transfer,proton exchange membrane | Conference | 1 |
ISSN | ISBN | Citations |
1557-170X | 1-4244-003303 | 1 |
PageRank | References | Authors |
0.67 | 1 | 5 |
Name | Order | Citations | PageRank |
|---|---|---|---|
| Gusphyl A Justin | 1 | 1 | 1.01 |
| M. Sun | 2 | 356 | 65.69 |
| Yingze Zhang | 3 | 2 | 1.71 |
| X Tracy Cui | 4 | 1 | 0.67 |
| Robert Sclabassi | 5 | 1 | 0.67 |