Name
Title | ||
|---|---|---|
Laser speckle imaging reveals multiple aspects of cerebral vascular responses to whole body mild hypothermia in rats. |
Abstract | ||
|---|---|---|
In this paper, we present a novel method to study the effect of induced mild hypothermia on cerebral vascular responses. To measure cerebral vascular responses, a minimally invasive imaging method, temporal laser speckle imaging, was developed and adapted for induced-hypothermia rat model. Experiments were carried out in rats under anesthesia. Laser speckle images were acquired at different temperature points, normothermia (37 °Q and mild therapeutic hypothermia (34 °Q. We extracted multiple hemodynamic responses simultaneously from the images, including blood flow, vessel size and deoxy-hemoglobin saturation. A wide-field view of the cerebral vascular response distribution was studied, which showed an inhomogeneous response map across the region of interest. A comparison between responses in arterioles and venules was carried out (blood flow decreased by 58 ± 9 % vs. 27 ± 8 %). The global decrease of blood flow, dilatation in arterioles and decrease of deoxy-hemoglobin saturation in veins at mild hypothermia suggests a beneficial role of circulatory and oxygenation changes in therapeutic hypothermia. The results reported provide a circulatory explanation for the hypothermia therapeutic effects and mechanism. |
Year | DOI | Venue |
|---|---|---|
2011 | 10.1109/IEMBS.2011.6090378 | EMBC |
Keywords | Field | DocType |
blood flow,mild therapeutic hypothermia,dilatation,biomedical optical imaging,temperature 34 degc,blood vessels,vessel size,proteins,temperature 37 degc,whole body mild hypothermia,arterioles,induced-hypothermia rat model,cerebral vascular response,laser speckle imaging,veins,laser applications in medicine,multiple hemodynamic response,venules,deoxy-hemoglobin saturation,circulatory explanation,medical image processing,haemodynamics,hemodynamic response,region of interest,lasers,speckle,imaging,reflectivity | Hemodynamics,Blood flow,Speckle pattern,Circulatory system,Anesthesia,Therapeutic effect,Oxygenation,Hypothermia,Laser Speckle Imaging,Medicine | Conference |
Volume | ISSN | ISBN |
2011 | 1557-170X | 978-1-4244-4122-8 |
Citations | PageRank | References |
0 | 0.34 | 1 |
Authors | ||
3 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Nan Li | 1 | 0 | 0.34 |
| Nitish V. Thakor | 2 | 31 | 9.92 |
| Xiaofeng Jia | 3 | 44 | 8.75 |