Name
Title | ||
|---|---|---|
Slowed propagation across the compacta-trabeculata interface: a consequence of fiber and sheet anisotropy. |
Abstract | ||
|---|---|---|
Transmural myocardial activation is influenced by myocardial structure, including structural differences between the compacta (Cta) and the trabeculata (Tta), although this has not been fully explained. Hearts from rats were Langendorff perfused, stained with DI-4-ANEPPS, the apex was cut off and fluorescence acquired from the exposed short-axis surface. The hearts were stimulated at 160 ms cycle length at the anterior, lateral, posterior left ventricle (LV) and septal sub-epicardial sites. Conduction velocity perpendicular to the wave front orientation was measured in each pixel using a gradient-based approach. After optical mapping the cut surface was imaged using a light microscope and the extent of the Cta and Tta mapped and validated against 50 u, m isotropic MRI images. We used a 3D rat ventricle computational model, with architecture obtained from 200 u, m isotropic diffusion tensor MRI and kinetics from the modified Pandit model to determine the relative roles of fibers and sheets on propagation. We show in the experimental study that circumferential propagation around the LV cavity is fast in the Cta: 63.2±19.5 and is slower in the Tta: 32.7±11.0(∗) (mean ± s.d cms-1, ∗ p < 0.01 by two sample t test). In the simulation study the pattern and velocity are not replicated in an isotropic model (I), are partially replicated in a simulation study including fiber anisotropy (A) and is more fully replicated in orthotropic (O) ventricles (fiber and sheet anisotropy), where the circumferential propagation velocity is, I: Cta: 54.2±3.9; Tta:54.3±3.9; A: Cta:43.6±3.2; Tta: 40.6±6.6; O: Cta: 63.2±19.5; Tta: 32.7±11.9(∗). We show that sheet orientation is important in understanding activation differences between Cta and Tta. |
Year | DOI | Venue |
|---|---|---|
2011 | 10.1109/IEMBS.2011.6090485 | EMBC |
Keywords | Field | DocType |
fiber anisotropy,gradient-based approach,cardiology,biomedical optical imaging,light microscope,conduction velocity,compacta-trabeculata interface,fluorescence,3d rat ventricle computational model,physiological models,biomedical mri,langendorff perfused rat heart,circumferential propagation velocity,optical microscopes,isotropic diffusion tensor mri,transmural myocardial activation,myocardial structure,optical mapping,orthotropic ventricles,left ventricle,muscle,sheet anisotropy,septal sub-epicardial sites,medical image processing,anisotropic magnetoresistance,heart,optical fiber,optical imaging,kinetics,computational modeling,computer model,optical fibers | Biomedical engineering,Isotropy,Optical fiber,Diffusion MRI,Perpendicular,Anisotropy,Optical mapping,Optical microscope,Fiber,Computer science | Conference |
Volume | ISSN | ISBN |
2011 | 1557-170X | 978-1-4244-4122-8 |
Citations | PageRank | References |
0 | 0.34 | 0 |
Authors | ||
4 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Stephen H. Gilbert | 1 | 15 | 4.55 |
| Alan P. Benson | 2 | 4 | 5.14 |
| Richard D Walton | 3 | 0 | 0.68 |
| Olivier Bernus | 4 | 7 | 5.37 |