Name
Title | ||
|---|---|---|
Optimal scaffold design and effective progenitor cell identification for the regeneration of vascularized bone. |
Abstract | ||
|---|---|---|
Bone tissue engineering offers perhaps the most attractive treatment option for bone repair/regeneration as it eliminates complications of other bone grafting options (i.e., availability and immunogenicity issues of autografts and allografts, respectively). However, scaffold-based bone tissue engineering is largely limited by inadequate vascaularization, and as a result, bone formation is often restricted to the construct's periphery. In this study, we offer a two-pronged approach to overcome periphery-limited bone and vascular formation. We have developed optimally designed, mechanically strong, biodegradable scaffolds with increased porosity and interconnectivity. We have also identified and isolated superior, clinically-relevant cell populations (peripheral blood-derived endothelial progenitor cells (EPCs), and bone marrow-derived mesenchymal stem cells (MSCs)). In combination, we have developed a synthetic graft system suitable for the regeneration of vascularized bone. |
Year | DOI | Venue |
|---|---|---|
2011 | 10.1109/IEMBS.2011.6090684 | EMBC |
Keywords | Field | DocType |
bone tissue engineering,msc,bone marrow-derived mesenchymal stem cells,cellular biophysics,interconnectivity,porosity,tissue engineering,optimal scaffold design,periphery-limited bone,progenitor cell identification,bone,synthetic graft system,peripheral blood-derived endothelial progenitor cells,biodegradable scaffolds,vascular formation,clinically-relevant cell population,bone repair-regeneration,epc,vascularized bone regeneration,media,mesenchymal stem cell,progenitor cell,optimal design,in vivo,stem cells,stem cell,in vitro | Biomedical engineering,Scaffold,Stem cell,Computer science,Mesenchymal stem cell,Bone healing,Tissue engineering,Bone grafting,Bone tissue,Progenitor cell | Conference |
Volume | ISSN | ISBN |
2011 | 1557-170X | 978-1-4244-4122-8 |
Citations | PageRank | References |
0 | 0.34 | 0 |
Authors | ||
2 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Syam P Nukavarapu | 1 | 0 | 0.68 |
| Ami R Amini | 2 | 0 | 0.34 |