Paper Info
Title
Next generation brain implant coatings and nerve regeneration via novel conductive nanocomposite development.
Abstract
Composite materials based on the coupling of conductive organic polymers and carbon nanotubes have shown that they possess properties of the individual components with a synergistic effect. Multi-wall carbon nanotube (MWCNT)/ polymer composites are hybrid materials that combine numerous mechanical, electrical and chemical properties and thus, constitute ideal biomaterials for a wide range of regenerative medicine applications. Although, complete dispersion of CNT in a polymer matrix has rarely been achieved, in this study we have succeeded high dispersibility of CNT in POSS-PCU and POSS-PCL, novel polymers based on polyprolactone and polycarbonate polyurethane (PCU) and poly(caprolactoneurea)urethane both having incorporated polyhedral oligomeric silsesquioxane (POSS). We report the synthesis and characterization of a novel biomaterial that possesses unique properties of being electrically conducting and thus being capable of electronic interfacing with tissue. To this end, POSS-PCU/MWCNT composite can be used as a biomaterial for the development of nerve guidance channels to promote nerve regeneration and POSS-PCL/MWCNT as a substrate to increase electronic interfacing between neurons and micro-machined electrodes for potential applications in neural probes, prosthetic devices and brain implants.
Year
DOI
Venue
2011
10.1109/IEMBS.2011.6090884
EMBC
Keywords
Field
DocType
polyprolactone,dispersibility,polycarbonate polyurethane,cellular biophysics,nanobiotechnology,novel conductive nanocomposite development,neurophysiology,biomedical materials,electrical properties,electrical conductivity,coated brain microelectrodes,composite materials,prosthetics,conductive organic polymer coupling,next generation brain implant coatings,regenerative medicine applications,nerve regeneration,chemical properties,multiwall carbon nanotube polymer composites,biomedical equipment,tissue,prosthetic devices,electronic interfacing,mechanical properties,carbon nanotubes,brain,polyhedral oligomeric silsesquioxane,neural probes,filled polymers,synergistic effect,microelectrodes,nanocomposites,nanomaterials,c,hybrid materials,poly(caprolactone-urea)urethane,biological tissues,neurons,disperse systems,coatings,brain implants,nerve guidance channels,micromachined electrodes,carbon nanotube,plastics,electric conductivity,regenerative medicine,chemicals,hybrid material,conductivity,composite material,impedance
Silsesquioxane,Nanotechnology,Hybrid material,Brain implant,Polymer,Biomaterial,Computer science,Nanocomposite,Carbon nanotube,Nanomaterials
Conference
Volume
ISSN
ISBN
2011
1557-170X
978-1-4244-4122-8
Citations 
PageRank 
References 
0
0.34
0
Authors
4
Name
Order
Citations
PageRank
Eleni V Antoniadou100.34
Rezal K Ahmad200.34
Richard B Jackman300.34
Alexander M Seifalian4728.65