Name
Title | ||
|---|---|---|
Approaches to optical neuromodulation from rodents to non-human primates by integrated optoelectronic devices. |
Abstract | ||
|---|---|---|
Methods on rendering neurons in the central nervous system to be light responsive has led to a boom in using optical neuromodulation as a new approach for controlling brain states and understanding neural circuits. In addition to the developing versatility to "optogenetically" labeling of neural cells and their subtypes by microbiological methods, parallel efforts are under way to design and implement optoelectronic devices to achieve simultaneous optical neuromodulation and electrophysiological recording with high spatial and temporal resolution. Such new device-based technologies need to be developed for full exploitation of the promise of optogenetics. In this paper we present single- and multi-element optoelectronic devices developed in our laboratories. The single-unit element, namely the coaxial optrode, was utilized to characterize the neural responses in optogenetically modified rodent and primate models. Furthermore, the multi-element device, integrating the optrode with a 6×6 microelectrode array, was used to characterize the spatiotemporal spread of neural activity in response to single-site optical stimulation in freely moving rats. We suggest that the particular approaches we employed can lead to the emergence of methods where spatio-temporal optical modulation is integrated with real-time read out from neural populations. |
Year | DOI | Venue |
|---|---|---|
2011 | 10.1109/IEMBS.2011.6091855 | EMBC |
Keywords | Field | DocType |
neural circuits,multielement device,coaxial optrode,freely moving rats,neurophysiology,nonhuman primates,integrated optoelectronic devices,spatio-temporal optical modulation,optogenetics,medical signal processing,neural cells,single-unit element,spatiotemporal phenomena,optical neuromodulation,physiological models,real-time read out,central nervous system,bioelectric phenomena,microbiological methods,spatiotemporal spread,integrated optoelectronics,biomedical electronics,spatial-temporal resolution,electrophysiological recording,brain states,real time,optical fibers,stimulated emission,optical modulator,microelectrode array,optical fiber,temporal resolution | Neuroscience,Optogenetics,Neurophysiology,Computer science,Electronic engineering,Neuromodulation,Biological neural network,Rendering (computer graphics),Optoelectronics,Temporal resolution,Multielectrode array,Optical recording | Conference |
Volume | ISSN | ISBN |
2011 | 1557-170X | 978-1-4244-4122-8 |
Citations | PageRank | References |
0 | 0.34 | 0 |
Authors | ||
12 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Jing Wang | 1 | 0 | 0.34 |
| Ilker Ozden | 2 | 0 | 0.34 |
| Mohamed Diagne | 3 | 0 | 0.34 |
| Fabien Wagner | 4 | 3 | 1.09 |
| David Borton | 5 | 0 | 0.34 |
| Benjamin Brush | 6 | 0 | 0.34 |
| Naubahar Agha | 7 | 1 | 0.82 |
| Rebecca Burwell | 8 | 0 | 0.34 |
| David Sheinberg | 9 | 0 | 0.34 |
| Ilka Diester | 10 | 0 | 0.34 |
| Karl Deisseroth | 11 | 0 | 0.34 |
| Arto Nurmikko | 12 | 1 | 0.82 |