Name
Abstract | ||
|---|---|---|
Affinity maturation, the fundamental basis for adaptive immunity, is accomplished through somatic hypermutation of B-cell receptors followed by expansion of rare mutants with higher affinity for the immunising antigen. This process occurs over a period of weeks in unique micro-anatomic sites known as germinal centres. Two-photon microscopy has recently made it possible to track individual cells moving within germinal centres in living animals. Here we apply statistical approaches to test the hypothesis that B-cell motion is random. Our results show that activated B cells move in a directed manner that sharply contrasts with the behaviour of naïve B cells. |
Year | DOI | Venue |
|---|---|---|
2011 | 10.1109/BIBM.2009.61 | International journal of data mining and bioinformatics |
Keywords | DocType | Volume |
two-photon microscopy,statistical analysis,computational immunology,cellular transport,germinal center,lymphocyte migration,optical microscopy,statistical approach,random walk,affinity maturation,activated germinal-center b cells,directed migration,two-photon spectroscopy | Journal | 5 |
Issue | ISSN | ISBN |
3 | 1748-5673 | 978-0-7695-3885-3 |
Citations | PageRank | References |
1 | 0.48 | 1 |
Authors | ||
4 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Mark J. O'Connor | 1 | 1 | 0.48 |
| Anja E. Hauser | 2 | 3 | 1.25 |
| Ann M. Haberman | 3 | 3 | 1.25 |
| Steven H Kleinstein | 4 | 95 | 16.45 |