Paper Info
Title
Electrical impedance spectroscopy for prostate cancer diagnosis.
Abstract
Electrical impedance was recorded at 21 discrete frequencies (1 to 100 kHz) from 27 ex vivo human prostates. These electrical properties were measured by using custom designed Electrical Impedance Spectroscopy (EIS) sensing biopsy (Bx) needles. EIS-Bx needles gauge the electrical properties of tissue in tandem with the tissue extraction (used for histopathological assessment). The EIS-Bx probe has a signal-to-noise ratio (SNR) of 65 dB across the frequency range (1 kHz to 100 kHz). A total of 36 cancers and 288 benign regions were sampled from 27 human prostates. Mean resistance (R) of prostate decreased from 537.27 Ω to 126.74 Ω for benign tissues and 999.52 Ω to 340.67 Ω for malignant tissues across the 1 kHz - 100 kHz spectral range. Likewise, mean reactance (X) ranged from -391.41 Ω to -62.6 Ω for benign and -675.09 Ω to -162.28 Ω for cancer tissues over the same frequency range. Both R and X values are found to be significantly lower in normal prostate tissues than in malignant tissue (p<0.001). Further testing to evaluate the clinical efficacy of this coupled device is underway.
Year
DOI
Venue
2012
10.1109/EMBC.2012.6346660
EMBC
Keywords
Field
DocType
histopathological assessment,benign tissue,resistance 126.74 ohm,eis-bx needle,resistance 999.52 ohm,electric impedance measurement,tissue extraction,cancer,biological tissue,electrical impedance spectroscopy,needles,resistance 340.67 ohm,eis sensing biopsy needle,malignant tissue,biological tissues,prostate cancer diagnosis,patient diagnosis,resistance 537.27 ohm
Biomedical engineering,Biopsy,Electrical impedance,Prostate cancer,Prostate,Electrical impedance spectroscopy,Medicine
Conference
Volume
ISSN
ISBN
2012
1557-170X
978-1-4577-1787-1
Citations 
PageRank 
References 
0
0.34
0
Authors
5
Name
Order
Citations
PageRank
V Mishra100.68
H Bouayad200.34
A. R. Schned3124.11
J Heaney400.34
R. J. Halter512626.47