Name
Title | ||
|---|---|---|
New approaches to bridge nerve gaps: development of a novel drug-delivering nerve conduit. |
Abstract | ||
|---|---|---|
Contemporary bridging techniques for repairing nerve gaps caused by trauma require autologous nerve grafts, which are difficult to harvest and handle and result in significant donor site deficit. Several nerve conduits with axon growth-enhancing potential have been proposed, developed and tested over the past fifteen years. In this work, prototypes of a nerve conduit designed to bridge large nerve gaps (≥10mm) end-to-end were incorporated with concentric drug reservoirs for constant and controlled drug delivery to enhance axon growth. These devices were designed, fabricated and tested in vitro in amber glass vials with bovine serum albumin in order to determine the drug release kinetics for future application. Our devices have shown the capability to deliver the drug of interest over a 6-day period. |
Year | DOI | Venue |
|---|---|---|
2012 | 10.1109/EMBC.2012.6346039 | EMBC |
Keywords | Field | DocType |
constant drug delivery,drug-delivering nerve conduit,axon growth-enhancing potential,nerve gaps,trauma,bovine serum albumin,blood vessels,time 6 day,injuries,bridging techniques,amber glass vials,drug delivery systems,autologous nerve grafts,concentric drug reservoirs,controlled drug delivery | Biomedical engineering,Computer science,Axon,Nerve guidance conduit,Surgery,Axon growth,Drug,Drug delivery | Conference |
Volume | ISSN | ISBN |
2012 | 1557-170X | 978-1-4577-1787-1 |
Citations | PageRank | References |
0 | 0.34 | 0 |
Authors | ||
4 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Keng-Min Lin | 1 | 0 | 0.34 |
| Himanshu Sant | 2 | 0 | 1.69 |
| Bruce K Gale | 3 | 0 | 1.69 |
| Jayant P Agarwal | 4 | 0 | 0.34 |