Paper Info
Title
Synchrony analysis of spontaneous MEG activity in Alzheimer's disease patients.
Abstract
The aim of this study was to analyze the magnetoencephalography (MEG) background activity in Alzheimer's disease (AD) patients using cross-approximate entropy (Cross-ApEn). Cross-ApEn is a nonlinear measure of asynchrony between time series. Five minutes of recording were acquired with a 148-channel whole-head magnetometer in 12 AD patients and 12 age-matched control subjects. We found significantly higher synchrony between MEG signals from AD patients compared with control subjects. Additionally, we evaluated the ability of Cross-ApEn to discriminate these two groups using receiver operating characteristic (ROC) curves with a leave-one-out cross-validation procedure. We obtained an accuracy of 70.83% (66.67% sensitivity, 75% specificity) and a value of area under the ROC curve of 0.83. These results provide evidence of disconnection problems in AD. Our findings show the usefulness of Cross-ApEn to detect the brain dysfunction in AD.
Year
DOI
Venue
2012
10.1109/EMBC.2012.6347407
EMBC
Keywords
Field
DocType
diseases,neurophysiology,leave-one-out cross-validation procedure,receiver operating characteristic curves,magnetoencephalography background activity,alzheimer's disease patients,cross-apen,disconnection problems,cross-approximate entropy,brain dysfunction,magnetoencephalography,148-channel whole-head magnetometer,entropy,time series,magnetometers,spontaneous meg activity synchrony analysis
Computer vision,Developmental psychology,Asynchrony,Disease,Receiver operating characteristic,Neurophysiology,Psychology,Artificial intelligence,Audiology,Area under the roc curve,Magnetoencephalography
Conference
Volume
ISSN
ISBN
2012
1557-170X
978-1-4577-1787-1
Citations 
PageRank 
References 
2
0.36
1
Authors
6
Name
Order
Citations
PageRank
Carlos Gómez18615.72
Mario Martínez-Zarzuela220.70
Jesús Poza371.38
Francisco J Díaz-Pernas420.36
Alberto Fernández514622.47
Hornero, R.6627.33