Paper Info
Title
Low frequency-modulated high frequency oscillations in seizure-like events recorded from in-vivo MeCP2-deficient mice.
Abstract
Rett syndrome is a neurodevelopmental condition caused by mutations in the gene encoding methyl CpG-binding protein 2 (MeCP2). Seizures are often associated with Rett syndrome and can be observed in intracranial electroencephalogram (iEEG) recordings. To date most studies have focused on the low frequencies oscillations (LFOs), however recent findings in epilepsy studies link high frequency oscillations (HFOs) with epileptogenesis. In this study, we examine the presence of HFOs in the male and female MeCP2-deficient mouse models of Rett syndrome and their interaction with the LFOs present during seizure-like events (SLEs). Our findings indicate that HFOs (200-600 Hz) are present during the SLEs and in addition, we reveal strong phase-amplitude coupling between LFOs (6-10 Hz) and HFOs (200-600 Hz) during female SLEs in the MeCP2-deficient mouse model.
Year
DOI
Venue
2013
10.1109/EMBC.2013.6609668
EMBC
Keywords
Field
DocType
frequency 6 hz to 10 hz,medical disorders,gene mutations,mecp2 encoding gene,rett syndrome,seizure like events,hfo,neurophysiology,intracranial electroencephalogram recordings,genetics,electroencephalography,in vivo mecp2 deficient mice,epileptogenesis,proteins,oscillations,neurodevelopmental condition,low frequency modulated high frequency oscillations,frequency 200 hz to 600 hz,ieeg recordings,lfo,phase amplitude coupling,methyl cpg-binding protein 2,couplings,frequency modulation,time frequency analysis
Rett syndrome,Neuroscience,Low frequency,Epileptogenesis,MECP2,Biology,Epilepsy,In vivo,METHYL-CpG-BINDING PROTEIN 2,Electroencephalography
Conference
Volume
ISSN
Citations 
2013
1557-170X
1
PageRank 
References 
Authors
0.48
3
6
Name
Order
Citations
PageRank
Sinisa Colic131.68
Min Lang210.48
Robert G Wither321.19
James H Eubanks420.85
Liang Zhang531.20
Berj L Bardakjian683.68