Paper Info
Title
Estimation of shear-stress-induced endothelial nitric oxide production from flow-mediated dilation.
Abstract
Vascular endothelial function assessment yields important diagnostic and prognostic information on patients with (or at risk of) cardiovascular diseases. Flow-mediated dilation (FMD) is the most widely used noninvasive method for assessing the endothelial function. In this method, the magnitude of FMD is used as a surrogate marker for the endothelial function. However, because vasodilation is affected by several other factors as well, the details of how this marker represents the endothelial function are not fully understood. Previously, we developed a mathematical model for vasodilation with intra- and intercellular pathways. In this study, we estimated the shear-stress-induced endothelial nitric oxide production from FMD measurements using the model. The results suggested that the accuracy of the estimated endothelial function obeys the characteristics of the shear stress added to the vascular wall. Furthermore, we showed that the FMD response describes not only the endothelial function but also vascular wall characteristics.
Year
DOI
Venue
2013
10.1109/EMBC.2013.6610552
EMBC
Keywords
Field
DocType
biomechanics,shear-stress estimation,intracellular pathway,cellular biophysics,nitrogen compounds,mathematical model,cardiovascular disease,cardiovascular system,physiological models,shear stress characteristics,fmd measurement,endothelial nitric oxide production,flow-mediated dilation,vascular endothelial function assessment,intercellular pathway,vascular wall characteristics,fmd response,vasodilation,no,physiology,estimation,stress,computational modeling,production
Cellular biophysics,Dilation (morphology),Biology,Shear stress,Nitric oxide,Vasodilation,Pathology
Conference
Volume
ISSN
Citations 
2013
1557-170X
0
PageRank 
References 
Authors
0.34
1
3
Name
Order
Citations
PageRank
Yoichi Yamazaki124.15
Yohei Kondo201.01
Y Kamiyama3125.61