Paper Info
Title
Three-dimensional modeling of oxidized-LDL accumulation and HDL mass transport in a coronary artery: a proof-of-concept study for predicting the region of atherosclerotic plaque development.
Abstract
Low density lipoprotein (LDL) has a significant role on the atherosclerotic plaque development, while the concentration of high density lipoproteins (HDL) is considered to play an atheroprotective role according to several biochemical mechanisms. In this work, it is the first time that both LDL and HDL concentrations are taken into account in order to predict the regions prone for plaque development. Our modeling approach is based on the use of a realistic three-dimensional reconstructed pig coronary artery in two time points. Biochemical data measured in the pig were also included in order to develop a more customized model. We modeled coronary blood flow by solving the Navier-Stokes equations in the arterial lumen and plasma filtration in the arterial wall using Darcy's Law. HDL transport was modeled only in the arterial lumen using the convection-diffusion equation, while LDL transport was modeled both in the lumen and the arterial wall. An additional novelty of this work is that we model the oxidation of LDL taking into account the atheroprotective role of HDL. The results of our model were in good agreement with histological findings demonstrating that increased oxidized LDL is found near regions of advanced plaques, while non-oxidized LDL is found in regions of early plaque types.
Year
DOI
Venue
2013
10.1109/EMBC.2013.6610550
EMBC
Keywords
Field
DocType
convection,darcy law,hdl mass transport,cardiology,diseases,oxidation,biodiffusion,atherosclerotic plaque development,convection-diffusion equation,plasma filtration,coronary blood flow model,blood vessels,three-dimensional pig coronary artery reconstruction,proteins,histological analysis,biochemistry,high density lipoprotein concentration,physiological models,molecular biophysics,biochemical mechanism,coronary artieral wall,oxidized-ldl accumulation,coronary arterial lumen,navier-stokes equation,biochemical data measurement,low density lipoprotein concentration,mass transfer,navier-stokes equations,haemodynamics,flow through porous media,mathematical model,solid modeling,convection diffusion equation,computational modeling
Artery,Oxidized ldl,Computer science,Low-density lipoprotein,Mass transport,Lumen (unit),Artificial intelligence,Pathology,Hemodynamics,Computer vision,Blood flow,Internal medicine,Cardiology,High density
Conference
Volume
ISSN
Citations 
2013
1557-170X
2
PageRank 
References 
Authors
0.65
1
11
Name
Order
Citations
PageRank
Antonis Sakellarios13218.83
Panagiotis K Siogkas252.84
Lambros S Athanasiou372.90
Themis P Exarchos474.66
Michail I Papafaklis5133.98
Christos V Bourantas672.64
Katerina K Naka7175.20
Lampros K Michalis873.65
Nenad Filipovic920.99
Oberdan Parodi1053.86
Dimitrios I Fotiadis114914.82