Name
Abstract | ||
|---|---|---|
In patients who have lost their photoreceptors due to retinal degenerative diseases, it is possible to restore rudimentary vision by electrically stimulating surviving neurons. AII amacrine cells, which reside in the inner plexiform layer, split the signal from rod bipolar cells into ON and OFF cone pathways. As a result, it is of interest to develop a computational model to aid in the understanding of how these cells respond to the electrical stimulation delivered by a prosthetic implant. The aim of this work is to develop and constrain parameters in a single-compartment model of an AII amacrine cell using data from whole-cell patch clamp recordings. This model will be used to explore responses of AII amacrine cells to electrical stimulation. Single-compartment Hodgkin-Huxley-type neural models are simulated in the NEURON environment. Simulations showed successful reproduction of the potassium currentvoltage relationship and some of the spiking properties observed in vitro. |
Year | DOI | Venue |
|---|---|---|
2013 | 10.1109/EMBC.2013.6611056 | EMBC |
Keywords | Field | DocType |
eye,potassium current-voltage relationship,neuron environment,cellular biophysics,diseases,electrically stimulating surviving neurons,neurophysiology,rod bipolar cells,spiking properties,rudimentary vision,single-compartment model,prosthetics,on cone pathways,electrical stimulation,off cone pathways,bioelectric phenomena,aii amacrine cells,potassium,retinal degenerative diseases,computational modeling,single-compartment hodgkin-huxley-type neural models,whole-cell patch clamp recordings,prosthetic implant,intrinsic electrophysiology modeling,photoreceptors,in vitro,data models,visualization,mathematical model | Neuroscience,Inner plexiform layer,Neurophysiology,Biology,Retinal,Neuron,Patch clamp,Electrophysiology,Stimulation,Amacrine cell | Conference |
Volume | ISSN | Citations |
2013 | 1557-170X | 0 |
PageRank | References | Authors |
0.34 | 0 | 5 |
Name | Order | Citations | PageRank |
|---|---|---|---|
| Nick Apollo | 1 | 0 | 0.34 |
| David B Grayden | 2 | 10 | 5.45 |
| Anthony N Burkitt | 3 | 4 | 4.21 |
| Hamish Meffin | 4 | 11 | 4.92 |
| Tatiana Kameneva | 5 | 14 | 7.38 |