Paper Info
Title
Integrated cellular and gene interaction model for cell migration in embryonic development
Abstract
The relationship between cellular behaviors and protein concentrations is central for embryonic development. An integrated cellular and gene interaction model is proposed to reveal this relationship. Protein concentrations vary spatiotemporally based on locations of cell, gene-gene interactions and the diffusion mechanism. On the other hand, cellular behaviors differentiate spatially, driven by cell-cell communication and protein concentrations in each cell. The model integrates a variation of the reaction-diffusion equation at the gene expression level and a particle-based cellular model based on the differential adhesion hypothesis for cell sorting at the cellular level. Cell sorting based on the adhesion hypothesis and patterns of inhibitory genes were simulated to illustrate the model. This model provides a more comprehensive basis to explain pattern formation during embryogenesis, than existing approaches that ignore the cellular components.
Year
DOI
Venue
2010
10.1109/BIBMW.2010.5703804
Bioinformatics and Biomedicine Workshops
Keywords
DocType
ISSN
adhesion,cellular biophysics,genetics,pattern formation,physiological models,proteins,reaction-diffusion systems,cell migration,cell sorting,cellular-gene interaction model,differential adhesion,diffusion,embryonic development,gene-gene interactions,inhibitory genes,protein concentrations,reaction-diffusion equation,embryonic multi-scale modelling,reaction-diffusion equations,mathematical model,computational modeling,adhesives,cellular model,reaction diffusion equations,cell communication,gene expression,reaction diffusion equation
Conference
2163-6966
ISBN
Citations 
PageRank 
978-1-4244-8304-4
0
0.34
References 
Authors
4
2
Name
Order
Citations
PageRank
Hien Nguyen100.34
Mingzhou Song200.34