Paper Info
Title
Remarks on structural identification, modularity, and retroactivity
Abstract
The “Modular Response Analysis” (MRA) reverse-engineering algorithm has been utilized in the systems biology literature in order to unravel the interactions between different “modules” in biochemical networks. We review the MRA technique, and discuss why its (mis-)application might lead to incorrect results due to impedance or load (“retroactivity”) effects, and present a computational criterion to discover stoichiometrically-dependent steady-state retroactivity.
Year
DOI
Venue
2010
10.1109/CDC.2010.5717595
Decision and Control
Keywords
Field
DocType
biochemistry,reverse engineering,biochemical network,modular response analysis reverse-engineering algorithm,stoichiometrically-dependent steady-state retroactivity,structural identification,structural modularity,structural retroactivity,systems biology
Response analysis,Control theory,Computer science,Reverse engineering,Systems biology,Modular design,Modularity
Conference
ISSN
ISBN
Citations 
0743-1546
978-1-4244-7745-6
0
PageRank 
References 
Authors
0.34
1
1
Name
Order
Citations
PageRank
Eduardo D. Sontag13134781.88