Paper Info
Title
Hybrid control of type 1 diabetes bolus therapy
Abstract
The probably best treatment of type 1 diabetes mellitus (T1DM) would be an artificial pancreas (AP). Unfortunately, AP is still not available as AP requires continuous glucose measurements and continuous insulin delivery systems which are not available. The vast majority of patients do not use any of them but instead resort to a few irregularly sampled measurements and single insulin administrations (`insulin bolus'). Choosing time and quantity of a bolus delivery is critical for the health of T1DM patients, and ideally this should be done on basis of a model. While good physiological models for populations exist, in general they can hardly be tuned to specific patients and are therefore not very useful for bolus choice. Against this background, this paper proposes to see the issue of model based bolus choice in a hybrid framework in which the continuous time meal and insulin model is replaced by a discrete parameterization which associates to each meal and bolus a function of given, patient specific shape whose amplitude depends on the respective amounts. This allows restating the standard model predictive control of the AP design by a line search method.
Year
DOI
Venue
2010
10.1109/CDC.2010.5717404
Decision and Control
Keywords
Field
DocType
diseases,patient treatment,predictive control,sugar,artificial pancreas,bolus therapy,discrete parameterization,glucose measurements,hybrid control,line search method,physiological models,predictive control,type 1 diabetes mellitus
Diabetes mellitus,Artificial pancreas,Computer science,Control theory,Model predictive control,Insulin,Type 1 diabetes,Bolus (digestion),Patient treatment
Conference
ISSN
ISBN
Citations 
0743-1546
978-1-4244-7745-6
0
PageRank 
References 
Authors
0.34
7
3
Name
Order
Citations
PageRank
Hannes Trogmann162.45
Harald Kirchsteiger2335.62
del Re, L.35213.29