Paper Info
Title
A Low-Noise Low-Power Noise-Adaptive Neural Amplifier in 0.13um CMOS Technology
Abstract
Chronic recording of neural signals is indispensable in designing efficient brain machine interfaces and in elucidating human neurophysiology. The advent of multichannel microelectrode arrays has driven the need for electronics to record neural signals from many neurons. The dynamic range of the system is limited by background system noise which varies over time. We propose a neural amplifier in UMC 130 nm, 2P8M CMOS technology. It can be biased adaptively from 200 nA to 2 uA, modulating input referred noise from 9.92 uV to 3.9 uV. We also describe a low noise design technique which minimizes the noise contribution of the load circuitry. The amplifier can pass signal from 5 Hz to 7 kHz while rejecting input DC offsets at electrode-electrolyte interface. The bandwidth of the amplifier can be tuned by the pseudo-resistor for selectively recording low field potentials (LFP) or extra cellular action potentials (EAP). The amplifier achieves a mid-band voltage gain of 37 dB and minimizes the attenuation of the signal from neuron to the gate of the input transistor. It is used in fully differential configuration to reject noise of bias circuitry and to achieve high PSRR.
Year
DOI
Venue
2011
10.1109/VLSID.2011.41
VLSI Design
Keywords
Field
DocType
CMOS analogue integrated circuits,bioelectric potentials,biomedical electronics,brain-computer interfaces,electrolytes,low noise amplifiers,microelectrodes,neurophysiology,operational amplifiers,CMOS technology,brain machine interface,chronic recording,current 200 nA to 2 muA,electrode-electrolyte interface,extra cellular action potentials,frequency 5 Hz to 7 kHz,human neurophysiology,low field potential,low noise design technique,low noise low power noise adaptive neural amplifier,multichannel microelectrode arrays,neural signals,pseudoresistor,size 0.13 mum,Neuron,action potentials,analog amplifier,bio-amplifier,flicker noise,large time constant,low noise,sub-threshold design
Low-noise amplifier,Fully differential amplifier,Computer science,Direct-coupled amplifier,Instrumentation amplifier,Electronic engineering,Noise temperature,Power supply rejection ratio,Effective input noise temperature,Electrical engineering,Operational amplifier
Conference
ISSN
ISBN
Citations 
1063-9667 E-ISBN : 978-0-7695-4348-2
978-0-7695-4348-2
4
PageRank 
References 
Authors
0.48
7
2
Name
Order
Citations
PageRank
Vikram Chaturvedi1243.41
Bharadwaj Amrutur245480.42