Name
Title | ||
|---|---|---|
High-power current source with real-time arbitrary waveforms for in vivo and in vitro studies of defibrillation |
Abstract | ||
|---|---|---|
Defibrillators are standard tools for treating cardiac fibrillation; however, the mechanisms by which they terminate deadly cardiac arrhythmias are still not fully understood, and optimizations to lower energies are very desirable. Clinical defibrillators do not provide a precise control of shock timing, duration, and voltage (current), and operate with fixed waveforms. Therefore, they are not suitable for research, particularly when studying low-energy defibrillation methods that require an examination of arbitrary and strictly timed waveform shocks of varying strength and duration. We present a custom-made microcontroller voltage-to-current converter (V2CC) with an output isolated from the Earth ground, capable of delivering up to 1 A continuously and up to 5 A into a 40 Ω load for >500 ms in a pulsed regime. For currents lower than 5 A, the load resistance can be higher, so that the product current times resistance is guaranteed to be up to 200 V. Bandwidth is in excess of 1 kHz, timing accuracy, response time, and rise and fall times are better than 10 μs. In addition, multiple safety mechanisms are implemented to protect the device and the operator. In our feedback control experiments the device has been tested successfully on isolated rabbit hearts. The V2CC is primarily designed to be used in ex vivo cardiac experiments, but is suitable for a wide variety of settings that require a high-current source of arbitrary waveforms. |
Year | Venue | Keywords |
|---|---|---|
2013 | CinC | bioelectric phenomena,cardiology,defibrillators,electric current control,medical control systems,medical disorders,microcontrollers,optimisation,patient treatment,real-time systems,voltage control,waveform analysis,earth ground,v2cc,arbitrary waveform shocks,cardiac arrhythmias,cardiac fibrillation treatment,clinical defibrillators,current 1 a,current 5 a,fall times,feedback control,fixed waveform,high-current source,high-power current source,isolated rabbit hearts,load resistance,low-energy defibrillation method,microcontroller voltage-to-current converter,multiple safety mechanisms,optimization,precise control,product current,pulsed regime,real-time arbitrary waveforms,resistance 40 ohm,response time,rise times,shock duration,shock timing,strictly timed waveform shocks,time 10 mus,timing accuracy,voltage 200 v,real time systems |
Field | DocType | Volume |
Defibrillation,Current source,Control theory,Computer science,Voltage,Waveform,Response time,Ground,Bandwidth (signal processing),Microcontroller | Conference | 40 |
ISSN | ISBN | Citations |
2325-8861 | 978-1-4799-0884-4 | 0 |
PageRank | References | Authors |
0.34 | 2 | 5 |
Name | Order | Citations | PageRank |
|---|---|---|---|
| ilija uzelac | 1 | 0 | 1.01 |
| Mark R. Holcomb | 2 | 0 | 0.68 |
| Ronald S. Reiserer | 3 | 0 | 0.68 |
| Flavio H. Fenton | 4 | 93 | 12.95 |
| John P. Wikswo | 5 | 3 | 2.26 |