Title
Novel Estimation of the Electrical Bioimpedance Using the Local Polynomial Method. Application to In Vivo Real-Time Myocardium Tissue Impedance Characterization During the Cardiac Cycle
Abstract
Classical measurements of myocardium tissue electrical impedance for characterizing the morphology of myocardium cells, as well as cell membranes integrity and intra/extra cellular spaces, are based on the frequency-sweep electrical impedance spectroscopy (EIS) technique. In contrast to the frequency-sweep EIS approach, measuring with broadband signals, i.e., multisine excitations, enables to collect, simultaneously, multiple myocardium tissue impedance data in a short measuring time. However, reducing the measuring time makes the measurements to be prone to the influence of the transients introduced by noise and the dynamic time-varying properties of tissue. This paper presents a novel approach for the impedance-frequency-response estimation based on the local polynomial method (LPM). The fast LPM version presented rejects the leakage error's influence on the impedance frequency response when measuring electrical bioimpedance in a short time. The theory is supported by a set of validation measurements. Novel preliminary experimental results obtained from real-time in vivo healthy myocardium tissue impedance characterization within the cardiac cycle using multisine excitation are reported.
Year
DOI
Venue
2011
10.1109/TBME.2011.2166116
Biomedical Engineering, IEEE Transactions
Keywords
Field
DocType
bioelectric phenomena,biological tissues,biomedical measurement,cardiology,cellular biophysics,electric impedance measurement,polynomial approximation,broadband signals,cardiac cycle,cell membrane integrity,electrical bioimpedance estimation,electrical impedance spectroscopy,extracellular spaces,fast LPM version,frequency sweep EIS,impedance frequency response estimation,in vivo real time myocardium electrical impedance,intracellular spaces,leakage error effects,local polynomial method,multiple myocardium tissue impedance data,multisine excitations,myocardium cell morphology,Broadband electrical impedance spectroscopy (EIS),electrical bioimpedance (EBI),local polynomial method (LPM),multisine excitation,myocardium tissue electrical impedance
Cellular biophysics,Frequency response,Leakage (electronics),Computer science,Electronic engineering,In vivo,Electrical impedance,Electrical impedance spectroscopy,Cardiac cycle,Polynomial method
Journal
Volume
Issue
ISSN
58
12
0018-9294
Citations 
PageRank 
References 
9
2.31
4
Authors
4
Name
Order
Citations
PageRank
Benjamin Sanchez1177.49
Schoukens, Johan217131.77
Bragos, R.3176.52
Vandersteen, G.47217.97