Name
Abstract | ||
|---|---|---|
KinMutBase (http://www.uta.fi/imt/bioinfo/KinMutBase/) is a registry of mutations in human protein kinases related to-disorders. Kinases are essential cellular signaling molecules, in which mutations can lead to diseases, including immunodeficiencies, cancers and endocrine disorders, The first release of KinMutBase contained information for protein tyrosine kinases. The current release includes also serine/threonine protein kinases, as well as an update of the tyrosine kinases, There are 251 entries altogether, representing 337 families and 621 patients. Mutations appear both in conserved hallmark residues of the kinases as well as in non-homologous sites. The KinMutBase WWW pages provide plenty of information, namely mutation statistics land display, clickable sequences with mutations and changes to restriction enzyme patterns. |
Year | DOI | Venue |
|---|---|---|
1999 | 10.1093/nar/28.1.369 | NUCLEIC ACIDS RESEARCH |
Keywords | Field | DocType |
conserved sequence,restriction mapping,signal transduction,mutation,internet,amino acid sequence,protein kinase,protein conformation,gene frequency,restriction enzyme,tyrosine kinase | Conserved sequence,Biology,Kinase,Protein-Serine-Threonine Kinases,Genetics,SH3 domain,Molecular biology,Serine/threonine-specific protein kinase,Receptor tyrosine kinase,Mutation,Tyrosine kinase | Journal |
Volume | Issue | ISSN |
28 | 1 | 0305-1048 |
Citations | PageRank | References |
3 | 0.48 | 2 |
Authors | ||
3 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Kaj A. E. Stenberg | 1 | 3 | 0.48 |
| Pentti Riikonen | 2 | 31 | 4.50 |
| Mauno Vihinen | 3 | 145 | 26.73 |