Title
The Cardiac Atlas Project--an imaging database for computational modeling and statistical atlases of the heart.
Abstract
Motivation: Integrative mathematical and statistical models of cardiac anatomy and physiology can play a vital role in understanding cardiac disease phenotype and planning therapeutic strategies. However, the accuracy and predictive power of such models is dependent upon the breadth and depth of noninvasive imaging datasets. The Cardiac Atlas Project (CAP) has established a large-scale database of cardiac imaging examinations and associated clinical data in order to develop a shareable, web-accessible, structural and functional atlas of the normal and pathological heart for clinical, research and educational purposes. A goal of CAP is to facilitate collaborative statistical analysis of regional heart shape and wall motion and characterize cardiac function among and within population groups. Results: Three main open-source software components were developed: (i) a database with web-interface; (ii) a modeling client for 3D + time visualization and parametric description of shape and motion; and (iii) open data formats for semantic characterization of models and annotations. The database was implemented using a three-tier architecture utilizing MySQL, JBoss and Dcm4chee, in compliance with the DICOM standard to provide compatibility with existing clinical networks and devices. Parts of Dcm4chee were extended to access image specific attributes as search parameters. To date, approximately 3000 de-identified cardiac imaging examinations are available in the database. All software components developed by the CAP are open source and are freely available under the Mozilla Public License Version 1.1 (http://www.mozilla.org/MPL/MPL-1.1.txt).
Year
DOI
Venue
2011
10.1093/bioinformatics/btr360
BIOINFORMATICS
Keywords
Field
DocType
computational biology,heart,diagnostic imaging
Heart shape,Open data,Data mining,Population,Computer science,Visualization,Medical imaging,Software,Cardiac imaging,Bioinformatics,Component-based software engineering,Database
Journal
Volume
Issue
ISSN
27
16
1367-4803
Citations 
PageRank 
References 
71
4.12
9
Authors
17
Name
Order
Citations
PageRank
Carissa G. Fonseca1876.34
Michael Backhaus21157.23
David A. Bluemke39311.78
Randall Britten41438.36
Jae Do Chung5745.01
Brett R. Cowan625323.58
Ivo D Dinov7744.54
J Paul Finn8714.12
Hunter P J91352177.64
Alan H. Kadish101197.37
Daniel C. Lee1131938.68
Jõao A. C. Lima121189.22
Pau Medrano-Gracia1316214.03
Kalyanam Shivkumar14714.45
Avan Suinesiaputra1523419.04
Wenchao Tao16936.58
Alistair A. Young1743353.11