Name
Abstract | ||
|---|---|---|
Wind-up, a condition related to chronic pain, is described traditionally as a frequency dependent increase in the excitability of sensory spinal cord neurons, evoked by electrical stimulation of small pain fibers. In this paper, we introduce a computational model on wind-up of large (A beta) fibers, considering three major mechanisms of wnd-up.1) a feedforward mechanism causing Ca2+ entry, 2) a positive feedback, causing more Ca2+ entry, and 3) a feedforward due to sprouting of All fibers towards the small pain fibers.Our model proposes three different ways for reducing windup and shows the most important way to treat the pain. |
Year | DOI | Venue |
|---|---|---|
2006 | 10.1109/IEMBS.2006.259604 | EMBC |
Keywords | DocType | Volume |
pain fibers,neurophysiology,positive feedback,computational modeling,computer model,calcium | Conference | 1 |
ISSN | Citations | PageRank |
1557-170X | 1 | 0.39 |
References | Authors | |
0 | 5 | |
Name | Order | Citations | PageRank |
|---|---|---|---|
| Aydin Farajidavar | 1 | 1 | 2.08 |
| Farzad Towhidkhah | 2 | 122 | 14.94 |
| Arash Mirhashemi | 3 | 1 | 0.39 |
| Shahriar Gharibzadeh | 4 | 2 | 0.80 |
| Khosrow Behbehani | 5 | 8 | 6.30 |