Paper Info
Title
Peg-B-Pcl And Peg-B-Pla Polymeric Micelles As Nanocarrieres For Lamellarin N Delivery
Abstract
Lamellarin N (Lam N) is a member of an interesting marine natural product class isolated from mollusks and subsequently found in ascidians and sponges. The limited aqueous solubility of Lam N hinders further studies on its cytotoxic activity against cancer cells. In this study, micelles comprising poly(ethylene glycol)-block-poly(epsilon-caprolactone) (PEG-b-PCL) and poly(ethylene glycol)-block-poly(D, L-lactide) (PEG-b-PLA) were developed to circumvent Lam N limited aqueous solubility. The results showed that an increase in the molecular weight of both core materials resulted in higher Lam N loading content, whereas the release of Lam N decreased as a function of molecular weight of PCL and PLA. With less hydrophobic property, PLA micelles provided faster Lam N release. Thus, polymeric micelles could be utilized as controlled-release delivery systems for poorly water soluble Lam N.
Year
DOI
Venue
2011
10.1109/IEMBS.2011.6090882
2011 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC)
Keywords
Field
DocType
molecular weight,programmable logic array,molecular biophysics,colloids,polymers,water soluble,cancer,controlled release,solubility
Polymer,Natural product,Ethylene glycol,Computer science,Micelle,Polymer chemistry,Electronic engineering,Colloid,Solubility,PEG ratio,Aqueous solution
Conference
Volume
ISSN
Citations 
2011
1557-170X
0
PageRank 
References 
Authors
0.34
0
7
Name
Order
Citations
PageRank
Pungkham Hathaichanok100.34
Swatdipakdi Nattharin200.34
Theerasilp Man300.34
Karnkla Supattra400.34
Chittchang Montakarn500.34
Ploypradith Poonsakdi600.34
Norased Nasongkla701.01