Paper Info
Title
Spatially dissociated flow-metabolism coupling in brain activation.
Abstract
The relationships among cerebral blood flow (CBF), oxygen consumption (CMRO2) and glucose use (CMRglc) constitute the basis of functional brain-imaging. Here we report spatially dissociated changes of CMRO2 and CBF during motor activity that lead us to propose a revision of conventional CBF-CMRO2 coupling models. In the left primary and supplementary motor cortices, CBF and CMRO2 rose significantly during finger-thumb tapping. However, in the right putamen CBF did not rise, despite a significant increase in CMRO2. We explain these observations by invoking a central command mechanism that regulates CBF in the putamen in anticipation of movement. By this mechanism, CBF rose in the putamen before the measurements of CBF and CMRO2 while CMRO2 rose when actual motion commenced.
Year
DOI
Venue
2004
10.1016/j.neuroimage.2003.10.003
NeuroImage
Keywords
DocType
Volume
Flow-metabolism,Brain activation,Functional brain-imaging
Journal
21
Issue
ISSN
Citations 
2
1053-8119
15
PageRank 
References 
Authors
3.42
5
2
Name
Order
Citations
PageRank
Manouchehr S. Vafaee1153.42
A GJEDDE2409.87