Paper Info
Title
Replication of SCN5A Associations with Electrocardio-graphic Traits in African Americans from Clinical and Epidemiologic Studies.
Abstract
The NAv1.5 sodium channel a subunit is the predominant alpha-subunit expressed in the heart and is associated with cardiac arrhythmias. We tested five previously identified SCN5A variants (rs7374138, rs7637849, rs7637849, rs7629265, and rs11129796) for an association with PR interval and QRS duration in two unique study populations: the Third National Health and Nutrition Examination Survey (NHANES III, n= 552) accessed by the Epidemiologic Architecture for Genes Linked to Environment (EAGLE) and a combined dataset (n= 455) from two biobanks linked to electronic medical records from Vanderbilt University (BioVU) and Northwestern University (NUgene) as part of the electronic Medical Records & Genomics (eMERGE) network. A metaanalysis including all three study populations (n similar to 4,000) suggests that eight SCN5A associations were significant for both QRS duration and PR interval (p < 5.0E-3) with little evidence for heterogeneity across the study populations. These results suggest that published SCN5A associations replicate across different study designs in a meta-analysis and represent an important first step in utility of multiple study designs for genetic studies and the identification/ characterization of genetic variants associated with ECG traits in Africandescent populations.
Year
DOI
Venue
2014
10.1007/978-3-662-45523-4_76
Lecture Notes in Computer Science
Keywords
Field
DocType
Electrocardiographic traits,African Americans,Genetic association study,Electronic medical records,eMERGE,Epidemiology,NHANES
Biobank,Demography,Biology,Epidemiology,Genomics,Clinical study design,Medical record,QRS complex,Bioinformatics,National Health and Nutrition Examination Survey,PR interval
Conference
Volume
ISSN
Citations 
8602
0302-9743
0
PageRank 
References 
Authors
0.34
0
21
Name
Order
Citations
PageRank
Janina M. Jeff100.68
Kristin Brown-Gentry201.35
Robert J. Goodloe322.45
Marylyn D Ritchie4194.31
Joshua C. Denny500.34
Abel N. Kho600.34
Loren L. Armstrong700.34
Bob McClellan Jr.800.34
Ping Mayo900.34
Melissa Allen1000.34
Hailing Jin1100.34
Niloufar B. Gillani1200.34
Nathalie Schnetz-Boutaud1300.34
Holli H Dilks1400.68
Melissa A. Basford1500.34
Jennifer A. Pacheco1610.73
Gail P. Jarvik1700.68
Rex L. Chisholm1800.34
Dan M Roden1900.68
M. Geoffrey Hayes20523.91
Dana C. Crawford2113714.54