Name
Title | ||
|---|---|---|
Label-free, single molecule resonant cavity detection: a double-blind experimental study. |
Abstract | ||
|---|---|---|
Optical resonant cavity sensors are gaining increasing interest as a potential diagnostic method for a range of applications, including medical prognostics and environmental monitoring. However, the majority of detection demonstrations to date have involved identifying a known analyte, and the more rigorous double-blind experiment, in which the experimenter must identify unknown solutions, has yet to be performed. This scenario is more representative of a real-world situation. Therefore, before these devices can truly transition, it is necessary to demonstrate this level of robustness. By combining a recently developed surface chemistry with integrated silica optical sensors, we have performed a double-blind experiment to identify four unknown solutions. The four unknown solutions represented a subset or complete set of four known solutions; as such, there were 256 possible combinations. Based on the single molecule detection signal, we correctly identified all solutions. In addition, as part of this work, we developed noise reduction algorithms. |
Year | DOI | Venue |
|---|---|---|
2015 | 10.3390/s150306324 | SENSORS |
Keywords | Field | DocType |
biosensors,optical resonators,single molecule detection | Noise reduction,Analytical chemistry,Resonant cavity,Prognostics,Molecule,Chemistry,Robustness (computer science),Electronic engineering,Analyte,Biosensor | Journal |
Volume | Issue | ISSN |
15 | 3 | 1424-8220 |
Citations | PageRank | References |
0 | 0.34 | 2 |
Authors | ||
3 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Maria V Chistiakova | 1 | 0 | 0.34 |
| Ce Shi | 2 | 0 | 0.34 |
| Andrea M Armani | 3 | 1 | 1.16 |