Paper Info
Title
Examining the regional and cerebral depth-dependent BOLD cerebrovascular reactivity response at 7 T.
Abstract
Changes in cerebral blood flow (CBF) in response to hypercapnia induced changes in vascular tone, known as cerebrovascular reactivity (CVR), can be measured using the Blood Oxygenation Level Dependent (BOLD) MR contrast. We examine regional differences in the BOLD-CVR response to a progressively increasing hypercapnic stimulus as well as regional BOLD characteristics for the return to baseline normocapnia. CVR across 9 subjects was highest in the cerebral lobes and deep gray matter. Peak CVR in these regions was measured at 3.6±1.6mmHg above baseline end-tidal CO2. White matter CVR was generally reduced compared to that of the gray matter (peak white matter CVR was ~48% lower). A positive relationship between the end-tidal CO2 value at which peak CVR was measured and white matter depth is observed. Furthermore, the time required for the BOLD signal to return to baseline after cessation of the hypercapnic stimulus, was also related to white matter depth; the return, expressed as a time constant, was ~25% longer in white matter. To explain the observed differences in regional CVR response, a model is proposed that takes into account the local architecture of the cerebrovascular, which can result in changes in regional blood flow distribution as a function of end-tidal CO2.
Year
DOI
Venue
2015
10.1016/j.neuroimage.2015.04.014
NeuroImage
Keywords
Field
DocType
7T,BOLD,CVR,Regional cerebrovascular reactivity,Hypercapnia,White matter
White matter,Blood flow,Anesthesia,Psychology,Arterial stiffness,Hypercapnia,Normocapnia,Cerebral blood flow,Blood oxygenation level dependent,Stimulus (physiology)
Journal
Volume
ISSN
Citations 
114
1053-8119
12
PageRank 
References 
Authors
0.72
11
7
Name
Order
Citations
PageRank
Alex A. Bhogal1292.89
Marielle E. P. Philippens2120.72
Jeroen C. W. Siero3575.09
Joseph A. Fisher4251.46
Esben Thade Petersen5120.72
Peter R. Luijten6211.52
Hans Hoogduin7120.72