Paper Info
Title
4D microvascular imaging based on ultrafast Doppler tomography.
Abstract
4D ultrasound microvascular imaging was demonstrated by applying ultrafast Doppler tomography (UFD-T) to the imaging of brain hemodynamics in rodents. In vivo real-time imaging of the rat brain was performed using ultrasonic plane wave transmissions at very high frame rates (18,000 frames per second). Such ultrafast frame rates allow for highly sensitive and wide-field-of-view 2D Doppler imaging of blood vessels far beyond conventional ultrasonography. Voxel anisotropy (100μm×100μm×500μm) was corrected for by using a tomographic approach, which consisted of ultrafast acquisitions repeated for different imaging plane orientations over multiple cardiac cycles. UFT-D allows for 4D dynamic microvascular imaging of deep-seated vasculature (up to 20mm) with a very high 4D resolution (respectively 100μm×100μm×100μm and 10ms) and high sensitivity to flow in small vessels (>1mm/s) for a whole-brain imaging technique without requiring any contrast agent. 4D ultrasound microvascular imaging in vivo could become a valuable tool for the study of brain hemodynamics, such as cerebral flow autoregulation or vascular remodeling after ischemic stroke recovery, and, more generally, tumor vasculature response to therapeutic treatment.
Year
DOI
Venue
2016
10.1016/j.neuroimage.2015.11.014
NeuroImage
Keywords
Field
DocType
Ultrasound imaging,Blood flow,Microvascular imaging,Ultrafast Doppler,3D rat brain,Tomography,Wiener filter
Voxel,Hemodynamics,Biomedical engineering,Ultrasonic sensor,Doppler imaging,Blood flow,Cognitive psychology,Tomography,Radiology,Doppler effect,Medicine,Ultrasound
Journal
Volume
ISSN
Citations 
127
1053-8119
3
PageRank 
References 
Authors
0.48
5
9
Name
Order
Citations
PageRank
Charlie Demené130.48
Elodie Tiran230.48
Lim-Anna Sieu330.48
Antoine Bergel430.48
Gennisson, J.-L.5113.50
Mathieu Pernot64010.82
Thomas Deffieux76211.58
Ivan Cohen8223.07
Mickael Tanter930.48