Paper Info
Title
From medical imaging to computer simulation of fractional flow reserve in four coronary artery trees
Abstract
We present the results of a computational study of coronary trees obtained from CT acquisition at resolution of 0.35mm x 0.35mm x 0.4mm and presenting significant stenotic plaques. We analyze the cardiovascular implications of stenotic plaques for a sizeable number of patients and show that the standard clinical criterion for surgical or percutaneous intervention, based on the Fractional Flow Reserve (FFR), is well reproduced by simulations in a range of inflow conditions that can be finely controlled. The relevance of the present study is related to the reproducibility of FFR data by simulating the coronary trees at global level via high performance simulation methods together with an independent assessment based on in vitro hemodynamics. The data show that controlling the flow Reynolds number is a viable procedure to account for FFR as heart-cycle time averages and maximal hyperemia, as measured in vivo. The reproducibility of the clinical data with simulation offers a systematic approach to measuring the functional implications of stenotic plaques.
Year
DOI
Venue
2014
10.1117/12.2043236
Proceedings of SPIE
Keywords
Field
DocType
Hemodynamics,Fractional Flow Reserve,Atherosclerotic plaques,High-Performance computing,Segmentation to Simulation pipeline,In vitro analysis
Artery,Reproducibility,Medical imaging,Fractional flow reserve,Artificial intelligence,High performance simulation,Hemodynamics,Computer vision,Simulation,Internal medicine,Cardiology,Computing systems,Physics
Conference
Volume
ISSN
Citations 
9035
0277-786X
0
PageRank 
References 
Authors
0.34
2
6
Name
Order
Citations
PageRank
simone melchionna183.12
stefania fortini200.34
Massimo Bernaschi350464.27
Mauro Bisson412612.11
Nahyup Kang5404.21
Hyong-euk Lee6999.55