Name
Title | ||
|---|---|---|
Identification of diurnal patterns in insulin action from measured CGM data for patients with T1DM |
Abstract | ||
|---|---|---|
We propose a method to identify diurnal changes in insulin action in patients suffering from type 1 diabetes mellitus (T1DM) based on data recorded by continuous glucose monitoring systems (CGMS). In order to do so the data is fitted using a continuous time transfer function including time dependent terms. The identified values for the insulin needs per gram of carbohydrate were compared with the patient-specific carbohydrate-to-insulin-ratios used for the calculation of the bolus insulin needs. A good agreement between the identified parameters and values determined by diabetologists were found. Furthermore, the diurnal variations in insulin action (as inferred from the changes in the patient-specific carbohydrate-to-insulin-ratios) could be reproduced. The identified models, including the diurnal changes in insulin action and the information on the intra-patient variability, have the potential to be used in future studies for managing the blood glucose level of patients, e.g. in a smart bolus calculator. |
Year | DOI | Venue |
|---|---|---|
2015 | 10.1109/ECC.2015.7330516 | 2015 European Control Conference (ECC) |
Keywords | Field | DocType |
Biomedical Systems,Blood Glucose Control,Type 1 Diabetes,System Identification | Diabetes mellitus,Continuous glucose monitoring,Internal medicine,Insulin,Type 1 diabetes,Bolus (digestion),Medicine,Endocrinology,Carbohydrate | Conference |
Citations | PageRank | References |
0 | 0.34 | 6 |
Authors | ||
4 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| florian reiterer | 1 | 0 | 0.34 |
| Harald Kirchsteiger | 2 | 33 | 5.62 |
| Guido Freckmann | 3 | 1 | 1.39 |
| Luigi del Re | 4 | 131 | 31.55 |