Paper Info
Title
Electrical impedance map (EIM) for margin assessment during robot-assisted laparoscopic prostatectomy (RALP) using a microendoscopic probe
Abstract
Background: Positive surgical margins (PSMs) found following prostate cancer surgery are a significant risk factor for post-operative disease recurrence. Noxious adjuvant radiation and chemical-based therapies are typically offered to men with PSMs. Unfortunately, no real-time intraoperative technology is currently available to guide surgeons to regions of suspicion during the initial prostatectomy where immediate surgical excisions could be used to reduce the chance of PSMs. Purpose: A microendoscopic electrical impedance sensing probe was developed with the intention of providing real-time feedback regarding margin status to surgeons during robot-assisted laparoscopic prostatectomy (RALP) procedures. Methodology: A radially configured 17-electrode microendoscopic probe was designed, constmcted, and initially evaluated through use of gelatin-based phantoms and an ex vivo human prostate specimen. Impedance measurements are recorded at 10 frequencies (10 kHz - 100 kHz) using a high-speed FPGAbased electrical impedance tomography (EIT) system. Tetrapolar impedances are recorded from a number of different electrode configurations strategically chosen to sense tissue in a pre-defined sector underlying the probe face. A circular electrical impedance map (EIM) with several color-coded pie-shaped sectors is created to represent the impedance values of the probed tissue. Results: Gelatin phantom experiments show an obvious distinction in the impedance maps between high and low impedance regions. Similarly, the EIM generated from the ex vivo prostate case shows distinguishing features between cancerous and benign regions. Based on successful development of this probe and these promising initial results, EIMs of additional prostate specimens are being collected to further evaluate this approach for intraoperative surgical margin assessment during RALP procedures.
Year
DOI
Venue
2015
10.1117/12.2082968
Proceedings of SPIE
Keywords
Field
DocType
Surgical margin,electrical impedance,microendoscopic probe,robot-assisted laparoscopic prostatectomy,impedance map,prostate cancer
Biomedical engineering,Positive Surgical Margin,Computer vision,Imaging phantom,Surgical margin,Tomography,Electrical impedance,Laparoscopic Prostatectomy,Prostatectomy,Artificial intelligence,Electrical impedance tomography,Physics
Conference
Volume
ISSN
Citations 
9415
0277-786X
0
PageRank 
References 
Authors
0.34
1
5
Name
Order
Citations
PageRank
Aditya Mahara172.69
Shadab Khan2236.45
A. R. Schned3124.11
elias s hyams442.25
R. J. Halter512626.47