Title
Analysis of elastography methods using mathematical and ex vivo data
Abstract
Intravascular ultrasound (IVUS) currently has a limited ability to characterize endovascular anatomic properties. IVUS elastography enhances the ability to characterize the biomechanical properties of arterial walls. A mathematical phantom generator was developed based on the characteristics of 30MHz, 64 element IVUS catheter images from excised canine femoral arteries. The difference between high and low-pressure intra-arterial images was modeled using phase shifts. The increase in phase shift occurred randomly, generally at every three pixels in our images. Using mathematical phantoms, different methods for calculating elastograms were quantitatively analyzed. Specifically, the effect of standard cross correlation versus cross correlation of the integral of the inflection characteristics for a given set of data, and the effect of an algorithm utilizing a non-constant kernel, were assessed. The specific methods found to be most accurate on the mathematical phantom data were then applied to ex vivo canine data of a scarred and a healthy artery. The algorithm detected significant differences between these two sets of arterial data. It will be necessary to obtain and analyze several more sets of canine arterial data in order to determine the accuracy and reproducibility of the algorithm.
Year
DOI
Venue
2003
10.1117/12.480309
Proceedings of SPIE
Keywords
Field
DocType
intra-vascular ultrasound imaging,elastography,image processing,mathematical phantom
Cross-correlation,Biomedical engineering,Ex vivo,Reproducibility,Intravascular ultrasound,Computer science,Imaging phantom,Image processing,Pixel,Elastography
Conference
Volume
ISSN
Citations 
5032
0277-786X
0
PageRank 
References 
Authors
0.34
0
5
Name
Order
Citations
PageRank
brett byram100.34
michael wahl200.34
David R Holmes34220.31
amir lerman400.68
Richard A. Robb5645238.12